前体引物的前景：诱导 CD4 结合位点定向艾滋病毒广泛中和抗体的进展

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-08-30 DOI:10.1126/sciimmunol.adq8862

Rama Rao Amara

引用次数: 0

摘要

设计用于激活 CD4 结合位点特异性中和抗体的生殖 B 细胞前体的 HIV 包膜免疫原在猴子身上显示出前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The promise of priming precursors: Advances in inducing CD4 binding site–directed HIV broadly neutralizing antibodies

HIV envelope immunogen designed to activate germline B cell precursors of CD4 binding site–specific neutralizing antibodies shows promise in monkeys.

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.