自主运动对高脂饮食和膳食高级糖化终产物喂养的中青年小鼠肝脏和脂肪组织功能障碍的影响

IF 3.5 2区 农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ruitong Liu, Tongtong Ma, Zhilong He, Guochong Chen, Huiwen Gu, Zhongxiao Wan
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引用次数: 0

摘要

目的:探讨自愿运动是否能够改善高脂饮食(HFD)和膳食高级糖化终产物(AGEs)导致的肝脏和脂肪组织功能障碍。 将中青年雄性C57BL/6J小鼠分为对照组、HFD组、HFD联合AGE组(HFD + AGE)和饮食与运动联合组(HFD + AGE + EX)。在幼鼠肝组织中,与YCON组相比,YHFD + AGE组的RAGE和YHFD + AGE及YHFD + AGE + EX组的SREBP1增加,而YHFD YHFD + AGE及YHFD + AGE + EX组的LXRα减少。在附睾脂肪中,YHFD 组的 CLOCK;YHFD + AGE 组的 RAGE、OST48、BMAL1 和 Rev-Erbα;YHFD + AGE + EX 组的 RAGE、OST48、CLOCK、BMAL1 和 Rev-Erbα;YHFD + AGE 组的 SIRT1;而 YHFD + AGE 组的 p-HSLser660 和 YHFD + AGE + EX 组的 p-Aktser473 则显著高于 YCON 组。此外,YHFD组和YHFD + AGE组的IL-10和IL-1Ra mRNA表达量明显降低,而YHFD + AGE + EX组的IL-10和IL-1Ra以及YHFD组、YHFD + AGE组和YHFD + AGE + EX组的TNF-α则明显升高。对于中年小鼠,在肝组织中,与 MACON 组相比,三个干预组的 CLOCK 和 Rev-Erbα 均升高,而 MAHFD 组和 MAHFD + AGE 组的 p-Aktser473 降低,MAHFD 组和 MAHFD + AGE 组的 PPARα 降低。在附睾脂肪中,与 MACON 组相比,MAHFD + AGE 组的 RAGE、MAHFD + AGE + EX 组的 p-Aktser473 和三个干预组的 TNF-α 基因表达量增加,而 MAHFD + AGE 组和 MAEX 组的 BMAL1 基因表达量增加;而 MAHFD + AGE 组的 BMAL1;MAHFD + AGE 组的 PPARγ 和 IL-1Ra;MAHFD 组、MAHFD + AGE 组和 MAHFD + AGE + EX 组的 SIRT1;MAHFD 组的脂肪连素;以及 MAHFD 组和 MAHFD + AGE 组的 p-HSLser660、ATGL 和 IL-10 均有所下降。总之,高密度脂蛋白膳食(HFD)和AGE膳食会导致肝脏和脂肪的糖脂代谢功能障碍,尤其是在中年小鼠中,而自主运动在一定程度上逆转了代谢异常,其机制在年轻小鼠和中年小鼠中有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of Voluntary Exercise on Liver and Adipose Tissue Dysfunction in Both Young and Middle-Aged Mice Fed a High-Fat Diet Combined with Dietary Advanced Glycation End Products

Effects of Voluntary Exercise on Liver and Adipose Tissue Dysfunction in Both Young and Middle-Aged Mice Fed a High-Fat Diet Combined with Dietary Advanced Glycation End Products

To determine whether voluntary exercise is capable of improving liver and adipose tissue dysfunction caused by the high-fat diet (HFD) combined with dietary advanced glycation end products (AGEs). Young and middle-aged male C57BL/6J mice were divided into the control group, HFD group, HFD combined AGE group (HFD + AGE), and combined diet with exercise group (HFD + AGE + EX). For young mice, in the liver tissue, compared to the YCON group, RAGE from the YHFD + AGE group and SREBP1 from the YHFD + AGE and YHFD + AGE + EX groups were increased, while LXRα from the YHFD YHFD + AGE, and YHFD + AGE + EX groups was decreased. In epididymal fat, CLOCK from the YHFD group; RAGE, OST48, BMAL1, and Rev-Erbα from the YHFD + AGE group; RAGE, OST48, CLOCK, BMAL1, and Rev-Erbα from the YHFD + AGE + EX group; SIRT1 from the YHFD + AGE group; adiponectin from the YHFD group; and ATGL from the YHFD and YHFD + AGE groups were significantly lower, while p-HSLser660 from the YHFD + AGE group and p-Aktser473 from the YHFD + AGE + EX group were significantly higher than in the YCON group. Additionally, IL-10 and IL-1Ra mRNA expressions from the YHFD and YHFD + AGE group were significantly decreased, while IL-10 and IL-1Ra from the YHFD + AGE + EX group and TNF-α from the YHFD, YHFD + AGE, and YHFD + AGE + EX groups were significantly increased. For middle-aged mice, in the liver tissue, compared to the MACON group, CLOCK and Rev-Erbα from three intervention groups were increased, while p-Aktser473 from the MAHFD and MAHFD + AGE groups was decreased and PPARα from the MAHFD and MAHFD + AGE groups was decreased. In epididymal fat, compared to the MACON group, RAGE from the MAHFD + AGE group; p-Aktser473 from the MAHFD + AGE + EX group; and TNF-α gene expressions from three intervention groups were increased, while BMAL1 from the MAHFD + AGE and MAEX groups; PPARγ and IL-1Ra from the MAHFD + AGE group; SIRT1 from the MAHFD, MAHFD + AGE, and MAHFD + AGE + EX groups; adiponectin from the MAHFD group; and p-HSLser660, ATGL, and IL-10 from the MAHFD and MAHFD + AGE groups were decreased. In conclusion, HFD combined with AGE diet caused dysfunction in the liver and adipose glucolipid metabolism, especially in middle-aged mice, and voluntary exercise reversed metabolic abnormalities to some extent with different mechanisms involved for young and middle-aged mice.

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来源期刊
Journal of Food Biochemistry
Journal of Food Biochemistry 生物-生化与分子生物学
CiteScore
7.80
自引率
5.00%
发文量
488
审稿时长
3.6 months
期刊介绍: The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality
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