{"title":"血友病患者 SEN 病毒流行情况调查","authors":"Davod Javanmard , Motahareh Mahi-Birjand , Effat Alemzadeh , Mahdie Mohammadi , Masood Ziaee","doi":"10.1016/j.nmni.2024.101470","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Hemophilia and transfusion-dependent patients are at high risk of a wide range of blood-borne agents. Among these, SEN virus (SENV) stands out as a significant concern due to its association with transfusion-induced non-A to non-E hepatitis. This study, therefore, aimed to investigate the prevalence of this virus in hemophilia patients, focusing on potential complications and risk factors.</p></div><div><h3>Method</h3><p>This was a cross-sectional study conducted in a hemophilia center in the east of Iran. Blood samples were taken from patients and healthy people, and demographic and clinical information was collected. The sera samples were then subjected to DNA extraction. PCR-based methods detected SENV and its genotype, and then phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS22 software.</p></div><div><h3>Results</h3><p>The mean age of patients and the healthy group was 26.18 ± 14.97 and 41.69 ± 14.05, respectively. Among the patient and healthy groups, 94.5 % and 36.4 % were male, and the rest were female, respectively. Most of the participants in the patient group had hemophilia type A (85.5 %), then type B (7.3 %), VWD type (3.6 %), and F and plt type (1.8 %) were in the next categories. SENV-DNA was detected in 58.2 % of patients and 20 % of healthy groups (P-value: 0.00). Among these, H and D genotypes were found in 35 % and 23.7 % of patients and 12.7 % and 7.3 % of healthy groups, respectively. The prevalence of the virus was significantly related to minor elevation of AST and was higher in hemophilia type A (63.8 %) and severe type of disease (63.2 %).</p></div><div><h3>Conclusion</h3><p>This study underscore the significant prevalence of the SENV virus in hemophilia patients, a particularly noteworthy finding compared to the healthy population. With the limited information available about this virus, our findings highlight the importance of continuous monitoring and follow-up of high-risk groups in relation to blood-borne pathogens, providing reassurance about the ongoing efforts in the field.</p></div>","PeriodicalId":38074,"journal":{"name":"New Microbes and New Infections","volume":"62 ","pages":"Article 101470"},"PeriodicalIF":2.9000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2052297524002543/pdfft?md5=3b058549663a1c772b26551c98dbe950&pid=1-s2.0-S2052297524002543-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Investigation of SEN virus prevalence in hemophilia patients\",\"authors\":\"Davod Javanmard , Motahareh Mahi-Birjand , Effat Alemzadeh , Mahdie Mohammadi , Masood Ziaee\",\"doi\":\"10.1016/j.nmni.2024.101470\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Hemophilia and transfusion-dependent patients are at high risk of a wide range of blood-borne agents. Among these, SEN virus (SENV) stands out as a significant concern due to its association with transfusion-induced non-A to non-E hepatitis. This study, therefore, aimed to investigate the prevalence of this virus in hemophilia patients, focusing on potential complications and risk factors.</p></div><div><h3>Method</h3><p>This was a cross-sectional study conducted in a hemophilia center in the east of Iran. Blood samples were taken from patients and healthy people, and demographic and clinical information was collected. The sera samples were then subjected to DNA extraction. PCR-based methods detected SENV and its genotype, and then phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS22 software.</p></div><div><h3>Results</h3><p>The mean age of patients and the healthy group was 26.18 ± 14.97 and 41.69 ± 14.05, respectively. Among the patient and healthy groups, 94.5 % and 36.4 % were male, and the rest were female, respectively. Most of the participants in the patient group had hemophilia type A (85.5 %), then type B (7.3 %), VWD type (3.6 %), and F and plt type (1.8 %) were in the next categories. SENV-DNA was detected in 58.2 % of patients and 20 % of healthy groups (P-value: 0.00). Among these, H and D genotypes were found in 35 % and 23.7 % of patients and 12.7 % and 7.3 % of healthy groups, respectively. The prevalence of the virus was significantly related to minor elevation of AST and was higher in hemophilia type A (63.8 %) and severe type of disease (63.2 %).</p></div><div><h3>Conclusion</h3><p>This study underscore the significant prevalence of the SENV virus in hemophilia patients, a particularly noteworthy finding compared to the healthy population. With the limited information available about this virus, our findings highlight the importance of continuous monitoring and follow-up of high-risk groups in relation to blood-borne pathogens, providing reassurance about the ongoing efforts in the field.</p></div>\",\"PeriodicalId\":38074,\"journal\":{\"name\":\"New Microbes and New Infections\",\"volume\":\"62 \",\"pages\":\"Article 101470\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2052297524002543/pdfft?md5=3b058549663a1c772b26551c98dbe950&pid=1-s2.0-S2052297524002543-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Microbes and New Infections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2052297524002543\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Microbes and New Infections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2052297524002543","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
背景血友病和输血依赖型患者面临多种血液传播病原体的高风险。其中，SEN 病毒（SENV）因其与输血引起的非 A 型至非 E 型肝炎有关而备受关注。因此，本研究旨在调查该病毒在血友病患者中的流行情况，重点关注潜在的并发症和风险因素。研究人员采集了患者和健康人的血样，并收集了人口统计学和临床信息。然后对血清样本进行 DNA 提取。基于 PCR 的方法检测 SENV 及其基因型，然后进行系统发育分析。结果 患者和健康组的平均年龄分别为（26.18±14.97）岁和（41.69±14.05）岁。在患者组和健康组中，男性和女性分别占 94.5% 和 36.4%。患者组中大多数人患有 A 型血友病（85.5%），其次是 B 型（7.3%）、VWD 型（3.6%）、F 型和 plt 型（1.8%）。在 58.2% 的患者和 20% 的健康人群中检测到 SENV-DNA（P 值：0.00）。其中，H 和 D 基因型分别在 35% 和 23.7% 的患者以及 12.7% 和 7.3% 的健康人群中发现。该病毒的流行与谷草转氨酶的轻微升高密切相关，在 A 型血友病（63.8%）和重症血友病（63.2%）中的流行率更高。由于有关该病毒的信息有限，我们的研究结果凸显了对血液传播病原体高危人群进行持续监测和随访的重要性，为该领域的持续努力提供了保证。
Investigation of SEN virus prevalence in hemophilia patients
Background
Hemophilia and transfusion-dependent patients are at high risk of a wide range of blood-borne agents. Among these, SEN virus (SENV) stands out as a significant concern due to its association with transfusion-induced non-A to non-E hepatitis. This study, therefore, aimed to investigate the prevalence of this virus in hemophilia patients, focusing on potential complications and risk factors.
Method
This was a cross-sectional study conducted in a hemophilia center in the east of Iran. Blood samples were taken from patients and healthy people, and demographic and clinical information was collected. The sera samples were then subjected to DNA extraction. PCR-based methods detected SENV and its genotype, and then phylogenetic analysis was performed. The collected data were analyzed and interpreted by SPSS22 software.
Results
The mean age of patients and the healthy group was 26.18 ± 14.97 and 41.69 ± 14.05, respectively. Among the patient and healthy groups, 94.5 % and 36.4 % were male, and the rest were female, respectively. Most of the participants in the patient group had hemophilia type A (85.5 %), then type B (7.3 %), VWD type (3.6 %), and F and plt type (1.8 %) were in the next categories. SENV-DNA was detected in 58.2 % of patients and 20 % of healthy groups (P-value: 0.00). Among these, H and D genotypes were found in 35 % and 23.7 % of patients and 12.7 % and 7.3 % of healthy groups, respectively. The prevalence of the virus was significantly related to minor elevation of AST and was higher in hemophilia type A (63.8 %) and severe type of disease (63.2 %).
Conclusion
This study underscore the significant prevalence of the SENV virus in hemophilia patients, a particularly noteworthy finding compared to the healthy population. With the limited information available about this virus, our findings highlight the importance of continuous monitoring and follow-up of high-risk groups in relation to blood-borne pathogens, providing reassurance about the ongoing efforts in the field.
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