在急性运动应激后,经常进行适度的体育锻炼可能会加速和加强促炎症和促溶解脂质介质的反应

IF 3
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引用次数: 0

摘要

随着时间的推移,PUFA 衍生的脂质介质反应会从促炎症转变为炎症消退,并且可能会因经常进行适度运动而改变。本研究旨在比较 18-35 岁男性休闲跑步者(n = 18)和不太活跃的对照组(n = 15)在不习惯阻力运动后白细胞中 PTGES2(COX2)和 ALOX15 的表达以及血浆中 5-和 15-HETE、18-HEPE 和 17-HDHA 的反应。深蹲、45°压腿和腿部伸展运动的单次最大重量(1RM)均已确定。随后以 80% 的 1RM 进行三组 8-10 次的重复训练,并在 72 小时内采集血液。在跑步者中,PTGES2 和 ALOX15 的表达随时间发生变化(P = 0.016,P = 0.007),而在对照组中则没有变化(P = 0.631,P = 0.539)。跑步者体内的 5-HETE 和 15-HETE 随着时间的推移而变化(P < 0.001,P = 0.022),而对照组则没有变化(P = 0.457,P = 0.985)。18-HEPE 在跑步者和对照组中均有变化(P < 0.001,P = 0.024),17-HDHA 在跑步者中有边缘性变化(P = 0.076)。总之,与运动量较少的对照组相比,休闲跑步者在剧烈阻力运动后,促炎症和炎症消除脂质介质可能会更快和更强地做出反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regular moderate physical activity potentially accelerates and strengthens both the pro-inflammatory and pro-resolving lipid mediator response after acute exercise stress

The PUFA-derived lipid mediator response shifts from pro-inflammatory to inflammation resolution over time and may be modified by regular moderate exercise. This pre-post-test study aimed to compare the expression of PTGES2 (COX2) and ALOX15 in leucocytes and the plasma 5- and 15-HETE, 18-HEPE and 17-HDHA responses after unaccustomed resistance exercise between 18–35-year-old male recreational runners (n = 18) and less-active controls (n = 15). One repetition maximum (1RM) was determined for squats, 45° leg presses and leg extensions. Subsequently three sets of 8–10 repetitions were performed at 80 % 1RM and blood collected over 72 hours. PTGES2 and ALOX15 expression changed over time in runners (P = 0.016, P = 0.007) but not controls (P = 0.631, P = 0.539). 5- and 15-HETE changed over time in runners (P < 0.001, P = 0.022), but not controls (P = 0.457, P = 0.985). 18-HEPE changed in runners and controls (P < 0.001, P = 0.024), 17-HDHA changed borderline in runners (P = 0.076). In conclusion, pro-inflammatory and inflammation-resolving lipid mediators may respond sooner and more robust in recreational runners than less-active controls after strenuous resistance exercise.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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0.00%
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审稿时长
64 days
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