最大耐受剂量(MTD)化疗是否是多形性胶质母细胞瘤的最佳化疗方案?

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Chiu-Yen Kao , Seyyed Abbas Mohammadi , Mohsen Yousefnezhad
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引用次数: 0

摘要

在本研究中,我们探讨了一个涉及反应-扩散偏微分方程(PDE)的控制问题。具体来说,重点是优化脑肿瘤治疗的化疗安排,以最大限度地减少化疗后的剩余肿瘤细胞。我们的研究结果表明,砰砰递增函数是唯一的解,从而肯定了 MTD 计划是最佳化疗方案。我们在真实的脑部图像上进行了几项数值实验,实验参数来自临床,肿瘤位于额叶、颞叶或枕叶。这些实验证实了我们的理论结果,并表明肿瘤增殖率与最佳治疗效果之间存在相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme?

In this study, we investigate a control problem involving a reaction–diffusion partial differential equation (PDE). Specifically, the focus is on optimizing the chemotherapy scheduling for brain tumor treatment to minimize the remaining tumor cells post-chemotherapy. Our findings establish that a bang-bang increasing function is the unique solution, affirming the MTD scheduling as the optimal chemotherapy profile. Several numerical experiments on a real brain image with parameters from clinics are conducted for tumors located in the frontal lobe, temporal lobe, or occipital lobe. They confirm our theoretical results and suggest a correlation between the proliferation rate of the tumor and the effectiveness of the optimal treatment.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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