稀土元素暴露与北京体外受精-胚胎移植结果之间的关系。

Yu Tong Wang, Jing Li, Shi Rong Xu, Sheng Li Lin, Zhen Chen Hou, Lin Lin Wang, Ya Li Huang, Yue Sun, Wei Guo, Lai Lai Yan, Ying Wang, Chan Tian
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引用次数: 0

摘要

目的:本研究旨在通过分析配偶样本,调查稀土元素(REEs)暴露对体外受精-胚胎移植(IVF-ET)妊娠结局的影响:该研究旨在通过分析配偶的样本,调查稀土元素(REEs)暴露对体外受精-胚胎移植(IVF-ET)妊娠结局的影响:方法:共纳入 141 对夫妇。采用电感耦合等离子体质谱法(ICP-MS)分析了妻子的血液和卵泡液以及丈夫的精浆中的 REEs。斯皮尔曼相关系数(Spearman's correlation coefficients)和曼-惠特尼 U 检验(Mann-Whitney U test)分别用于评估相关性和比较三种样本中的 REE 浓度。利用逻辑模型估算了单个 REE 对 IVF-ET 结果的影响,而 BKMR 和 WQS 模型则探讨了 REE 对 IVF-ET 结果的混合交互影响:精液中La浓度越高(中位数为0.089纳克/毫升,P = 0.03),受精率越低。然而,在通过卵胞浆内单精子显微注射(ICSI)进行人工选择干预后,就观察不到这种影响了(P = 0.27)。在精液中,REEs混合物与临床妊娠无明显关联:我们的研究揭示了精液中的高镭暴露与受精率下降之间的潜在联系,但与临床妊娠率无关。这是首次报告卵泡液中的 REEs 浓度,其中 La、Ce、Pr 和 Nd 的浓度明显低于血清中的浓度,这表明这四种 REEs 可能不会在女性生殖系统中蓄积。不过,在目前的暴露水平下,混合 REEs 暴露并未表现出生殖毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing.

Objective: The study aimed to investigate the impact of rare earth elements (REEs) exposure on pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) by analyzing samples from spouses.

Methods: A total of 141 couples were included. Blood and follicular fluid from the wives and semen plasma from the husbands, were analyzed for REEs using inductively coupled plasma mass spectrometry (ICP-MS). Spearman's correlation coefficients and the Mann-Whitney U test were used to assess correlations and compare REE concentrations among three types of samples, respectively. Logistic models were utilized to estimate the individual REE effect on IVF-ET outcomes, while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET outcomes.

Results: Higher La concentration in semen (median 0.089 ng/mL, P = 0.03) was associated with a lower fertilization rate. However, this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection (ICSI) ( P = 0.27). In semen, the REEs mixture did not exhibit any significant association with clinical pregnancy.

Conclusion: Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate, but not clinical pregnancy rate. This is the first to report REEs concentrations in follicular fluid with La, Ce, Pr, and Nd found at significantly lower concentrations than in serum, suggesting that these four REEs may not accumulate in the female reproductive system. However, at the current exposure levels, mixed REEs exposure did not exhibit reproductive toxicity.

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