甘油三酯血糖指数、空腹血糖和口服葡萄糖耐量试验对有 GDM 病史妇女产后高血糖的预测能力。

IF 1.7 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Geng Song, Yumei Wei, Juan Juan, Jianhua Niu, Huixia Yang
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引用次数: 0

摘要

研究目的本研究旨在确定妊娠期糖尿病(GDM)产妇产后发生高血糖的可能性,并找出预测因素:这项回顾性队列研究涉及1 527名妊娠期糖尿病(GDM)患者,她们于2021年1月1日至2021年12月31日在北京大学第一医院分娩。根据产后口服葡萄糖耐量试验(OGTT)的血糖水平,将产妇分为糖耐量正常(NGT)组和高血糖组,比较两组产妇的特征和高血糖的风险因素:结果:产后 6-12 周时,高血糖发生率为 33.9%(184/543)。与 NGT 组相比,高血糖组的空腹血浆葡萄糖(FPG)在孕期和产后显著升高,OGTT 餐后 1 小时血糖(PG)和 2 小时血糖(PPG)在孕期后三个月升高,甘油三酯(TG)在孕期前三个月和产后升高、甘油三酯葡萄糖(TyG)指数在妊娠头三个月和产后增加,总胆固醇(TCHO)和低密度脂蛋白胆固醇(LDL-C)在妊娠后三个月下降(p p p = 0.045)和第三孕期的 FPG(OR = 1.985,P = 0.024)是产后高血糖的独立危险因素:结论:大约三分之一的 GDM 妇女在产后 6-12 周出现高血糖。结论:约有三分之一的 GDM 妇女在产后 6-12 周出现高血糖,妊娠前三个月的 FPG 和 TyG 指数、妊娠后三个月的 OGTT 2hPG 和妊娠后三个月的 FPG 是产后高血糖的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The predictive ability of the triglyceride glucose index, fasting glucose and oral glucose tolerance test for postpartum hyperglycemia in women with a GDM history.

Objective: This study aimed to determine the likelihood of hyperglycemia postpartum in women with gestational diabetes mellitus (GDM) and to identify the predictors.

Methods: The retrospective cohort study involved 1 527 GDM patients who delivered at Peking University First Hospital from 1 January 2021, to 31 December 2021. According to the blood glucose level of postpartum oral glucose tolerance test (OGTT), women were divided into a normal glucose tolerance (NGT) group and a hyperglycemia group, and their characteristics and risk factors of hyperglycemia were compared.

Results: The prevalence of hyperglycemia was 33.9% (184/543) at 6-12 weeks postpartum. Compared with the NGT group, the fasting plasma glucose (FPG) of hyperglycemia group increased significantly during pregnancy and postpartum, the OGTT 1h postprandial glucose (PG) and 2hPG increased in the second trimester of pregnancy, the triglyceride (TG) increased in the first trimester of pregnancy and postpartum, the triglyceride glucose (TyG) index increased in the first trimester of pregnancy and postpartum, and the total cholesterol (TCHO) and low density lipoprotein cholesterol (LDL-C) decreased in the second trimester (p < 0.05). Fasting plasma glucose (FPG) in the first trimester [odds ratio (OR) = 3.583, p < 0.001], OGTT 2hPG in the second trimester (OR = 1.604, p < 0.001), the TyG index in the first trimester (OR = 1.863, p = 0.045) and FPG in third trimester (OR = 1.985, p = 0.024) were independent risk factors for postpartum hyperglycemia.

Conclusions: Approximately one-third of women with GDM have hyperglycemia 6-12 weeks after delivery. FPG and the TyG index in the first trimester, OGTT 2hPG in the second trimester and FPG in third trimester are risk factors for postpartum hyperglycemia.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
217
审稿时长
2-3 weeks
期刊介绍: The official journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies and The International Society of Perinatal Obstetricians. The journal publishes a wide range of peer-reviewed research on the obstetric, medical, genetic, mental health and surgical complications of pregnancy and their effects on the mother, fetus and neonate. Research on audit, evaluation and clinical care in maternal-fetal and perinatal medicine is also featured.
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