Ayushi Trivedi, Dipro Bose, Kelly Moffat, Elisabeth Pearson, Dana Walsh, Devra Cohen, Jonathan Skupsky, Linda Chao, Julia Golier, Patricia Janulewicz, Kimberly Sullivan, Maxine Krengel, Ashok Tuteja, Nancy Klimas, Saurabh Chatterjee
{"title":"海湾战争疾病与宿主肠道微生物组失调有关,并与 BBRAIN 队列中退伍军人物种丰度的改变有关。","authors":"Ayushi Trivedi, Dipro Bose, Kelly Moffat, Elisabeth Pearson, Dana Walsh, Devra Cohen, Jonathan Skupsky, Linda Chao, Julia Golier, Patricia Janulewicz, Kimberly Sullivan, Maxine Krengel, Ashok Tuteja, Nancy Klimas, Saurabh Chatterjee","doi":"10.3390/ijerph21081102","DOIUrl":null,"url":null,"abstract":"<p><p>Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990-1991 Gulf War. Fatigue, GI complaints, and other chronic symptoms continue to persist more than 30 years post-deployment. Several potential mechanisms for the persistent illness have been identified and our prior pilot study linked an altered gut microbiome with the disorder. This study further validates and builds on our prior preliminary findings of host gut microbiome dysbiosis in veterans with GWI. Using stool samples and Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases and 26 controls) from the Boston biorepository, recruitment, and integrative network (BBRAIN) for Gulf War Illness, we found that the host gut bacterial signature of veterans with GWI showed significantly different Bray-Curtis beta diversity than control veterans. Specifically, a higher <i>Firmicutes</i> to <i>Bacteroidetes</i> ratio, decrease in <i>Akkermansia</i> sp., <i>Bacteroides thetaiotamicron</i>, <i>Bacteroides fragilis</i>, and <i>Lachnospiraceae</i> genera and increase in <i>Blautia</i>, <i>Streptococcus</i>, <i>Klebsiella</i>, and <i>Clostridium</i> genera, that are associated with gut, immune, and brain health, were shown. Further, using MaAsLin and Boruta algorithms, <i>Coprococcus</i> and <i>Eisenbergiella</i> were identified as important predictors of GWI with an area under the curve ROC predictive value of 74.8%. Higher self-reported MFI scores in veterans with GWI were also significantly associated with an altered gut bacterial diversity and species abundance of <i>Lachnospiraceae</i> and <i>Blautia</i>. These results suggest potential therapeutic targets for veterans with GWI that target the gut microbiome and specific symptoms of the illness.</p>","PeriodicalId":49056,"journal":{"name":"International Journal of Environmental Research and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354743/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort.\",\"authors\":\"Ayushi Trivedi, Dipro Bose, Kelly Moffat, Elisabeth Pearson, Dana Walsh, Devra Cohen, Jonathan Skupsky, Linda Chao, Julia Golier, Patricia Janulewicz, Kimberly Sullivan, Maxine Krengel, Ashok Tuteja, Nancy Klimas, Saurabh Chatterjee\",\"doi\":\"10.3390/ijerph21081102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990-1991 Gulf War. Fatigue, GI complaints, and other chronic symptoms continue to persist more than 30 years post-deployment. Several potential mechanisms for the persistent illness have been identified and our prior pilot study linked an altered gut microbiome with the disorder. This study further validates and builds on our prior preliminary findings of host gut microbiome dysbiosis in veterans with GWI. Using stool samples and Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases and 26 controls) from the Boston biorepository, recruitment, and integrative network (BBRAIN) for Gulf War Illness, we found that the host gut bacterial signature of veterans with GWI showed significantly different Bray-Curtis beta diversity than control veterans. Specifically, a higher <i>Firmicutes</i> to <i>Bacteroidetes</i> ratio, decrease in <i>Akkermansia</i> sp., <i>Bacteroides thetaiotamicron</i>, <i>Bacteroides fragilis</i>, and <i>Lachnospiraceae</i> genera and increase in <i>Blautia</i>, <i>Streptococcus</i>, <i>Klebsiella</i>, and <i>Clostridium</i> genera, that are associated with gut, immune, and brain health, were shown. Further, using MaAsLin and Boruta algorithms, <i>Coprococcus</i> and <i>Eisenbergiella</i> were identified as important predictors of GWI with an area under the curve ROC predictive value of 74.8%. Higher self-reported MFI scores in veterans with GWI were also significantly associated with an altered gut bacterial diversity and species abundance of <i>Lachnospiraceae</i> and <i>Blautia</i>. These results suggest potential therapeutic targets for veterans with GWI that target the gut microbiome and specific symptoms of the illness.</p>\",\"PeriodicalId\":49056,\"journal\":{\"name\":\"International Journal of Environmental Research and Public Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354743/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Environmental Research and Public Health\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.3390/ijerph21081102\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Research and Public Health","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.3390/ijerph21081102","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort.
Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990-1991 Gulf War. Fatigue, GI complaints, and other chronic symptoms continue to persist more than 30 years post-deployment. Several potential mechanisms for the persistent illness have been identified and our prior pilot study linked an altered gut microbiome with the disorder. This study further validates and builds on our prior preliminary findings of host gut microbiome dysbiosis in veterans with GWI. Using stool samples and Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases and 26 controls) from the Boston biorepository, recruitment, and integrative network (BBRAIN) for Gulf War Illness, we found that the host gut bacterial signature of veterans with GWI showed significantly different Bray-Curtis beta diversity than control veterans. Specifically, a higher Firmicutes to Bacteroidetes ratio, decrease in Akkermansia sp., Bacteroides thetaiotamicron, Bacteroides fragilis, and Lachnospiraceae genera and increase in Blautia, Streptococcus, Klebsiella, and Clostridium genera, that are associated with gut, immune, and brain health, were shown. Further, using MaAsLin and Boruta algorithms, Coprococcus and Eisenbergiella were identified as important predictors of GWI with an area under the curve ROC predictive value of 74.8%. Higher self-reported MFI scores in veterans with GWI were also significantly associated with an altered gut bacterial diversity and species abundance of Lachnospiraceae and Blautia. These results suggest potential therapeutic targets for veterans with GWI that target the gut microbiome and specific symptoms of the illness.
期刊介绍:
International Journal of Environmental Research and Public Health (IJERPH) (ISSN 1660-4601) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes, and short communications in the interdisciplinary area of environmental health sciences and public health. It links several scientific disciplines including biology, biochemistry, biotechnology, cellular and molecular biology, chemistry, computer science, ecology, engineering, epidemiology, genetics, immunology, microbiology, oncology, pathology, pharmacology, and toxicology, in an integrated fashion, to address critical issues related to environmental quality and public health. Therefore, IJERPH focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health.
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