利用临床特征和磁共振成像放射组学数据预测舌鳞状细胞癌患者总生存期的新型提名图:一项试点研究。

IF 2.5 3区 医学 Q3 ONCOLOGY
Yongling Yao, Xin Jin, Tianfang Peng, Ping Song, Yingjian Ye, Lina Song, Huantian Li, Peng An
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引用次数: 0

摘要

研究目的在中国,舌鳞状细胞癌(TSCC)占口腔癌的43.4%,预后较差。本研究旨在探讨从术前磁共振成像(MRI)中提取的放射组学特征能否预测TSCC患者的总生存期(OS):方法:回顾性分析2010年2月至2022年10月期间襄阳市第一人民医院病理确诊的232例TSCC患者的临床影像学资料。根据2-10年的随访,将患者分为两组:对照组(健康生存,148人)和研究组(不良事件:复发或转移相关死亡,84人)。按照 7:3 的比例和时间节点建立了训练集和测试集。从轴向 T2 加权成像、对比增强 T1 加权成像和弥散加权成像(DWI)序列中提取放射组学特征。使用最小绝对收缩和选择算子算法生成相应的放射组学评分。采用 Kaplan-Meier 和多变量 Cox 回归分析,利用临床和病理结果筛选影响 TSCC 患者不良事件的独立因素。建立了一个新的提名图来预测TSCC患者发生不良事件的概率和OS:结果:术后2-10年内不良事件的发生率为36.21%。Kaplan-Meier分析显示,吃火锅、嚼槟榔、血小板-淋巴细胞比率、药物使用、中性粒细胞-淋巴细胞比率、Radscore和其他因素影响TSCC的生存率。多变量 Cox 回归分析显示,训练集和测试集中的临床分期(P 0.05)能准确预测不良事件和生存风险:结论:利用临床数据和磁共振成像放射组学参数构建的提名图可以无创准确预测 TSCC-OS,从而帮助临床医生及时调整治疗策略,改善患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel nomogram for predicting overall survival in patients with tongue squamous cell carcinoma using clinical features and MRI radiomics data: a pilot study.

Objective: Tongue squamous cell carcinoma (TSCC) accounts for 43.4% of oral cancers in China and has a poor prognosis. This study aimed to explore whether radiomics features extracted from preoperative magnetic resonance imaging (MRI) could predict overall survival (OS) in patients with TSCC.

Methods: The clinical imaging data of 232 patients with pathologically confirmed TSCC at Xiangyang No. 1 People's Hospital were retrospectively analyzed from February 2010 to October 2022. Based on 2-10 years of follow-up, patients were categorized into two groups: control (healthy survival, n = 148) and research (adverse events: recurrence or metastasis-related death, n = 84). A training and a test set were established using a 7:3 ratio and a time node. Radiomics features were extracted from axial T2-weighted imaging, contrast-enhanced T1-weighted imaging, and diffusion-weighted imaging (DWI) sequences. The corresponding radiomics scores were generated using the least absolute shrinkage and selection operator algorithm. Kaplan-Meier and multivariate Cox regression analyses were used to screen for independent factors affecting adverse events in patients with TSCC using clinical and pathological results. A novel nomogram was established to predict the probability of adverse events and OS in patients with TSCC.

Results: The incidence of adverse events within 2-10 years after surgery was 36.21%. Kaplan-Meier analysis revealed that hot pot consumption, betel nut chewing, platelet-lymphocyte ratio, drug use, neutrophil-lymphocyte ratio, Radscore, and other factors impacted TSCC survival. Multivariate Cox regression analysis revealed that the clinical stage (P < 0.001), hot pot consumption (P < 0.001), Radscore 1 (P = 0.01), and Radscore 2 (P < 0.001) were independent factors affecting TSCC-OS. The same result was validated by the XGBoost algorithm. The nomogram based on the aforementioned factors exhibited good discrimination (C-index 0.86/0.81) and calibration (P > 0.05) in the training and test sets, accurately predicting the risk of adverse events and survival.

Conclusion: The nomogram constructed using clinical data and MRI radiomics parameters may accurately predict TSCC-OS noninvasively, thereby assisting clinicians in promptly modifying treatment strategies to improve patient prognosis.

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来源期刊
CiteScore
4.70
自引率
15.60%
发文量
362
审稿时长
3 months
期刊介绍: World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
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