泛素结合酶在精子发生过程中的作用

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2024-08-28 DOI:10.1186/s12958-024-01282-y

Peng Lv, Jihong Liu, Xiaming Liu

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引用次数: 0

摘要

泛素化是控制细胞平衡和蛋白质修饰的关键，其中泛素结合酶（E2）是泛素化系统的核心角色。泛素结合酶具有催化底物的特殊结构域，其序列存在差异，在多种生物的不同细胞中调节各种病理生理过程。E2s 参与原始生殖细胞的有丝分裂、精母细胞的减数分裂和成熟单倍体精子的形成，以维持男性的正常生育能力。在这篇综述中，我们总结了精子发生不同阶段的各种类型的E2s及其功能。

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The role of ubiquitin-conjugating enzyme in the process of spermatogenesis.

The ubiquitination is crucial for controlling cellular homeostasis and protein modification, in which ubiquitin-conjugating enzyme (E2) acts as the central player in the ubiquitination system. Ubiquitin-conjugating enzymes, which have special domains that catalyse substrates, have sequence discrepancies and modulate various pathophysiological processes in different cells of multiple organisms. E2s take part in the mitosis of primordial germ cells, meiosis of spermatocytes and the formation of mature haploid spermatids to maintain normal male fertility. In this review, we summarize the various types of E2s and their functions during distinct stages of spermatogenesis.

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.