印度尼西亚苏拉威西岛东南部瓦卡托比地区 5 岁以下海上游牧民族儿童肺炎链球菌的流行率、血清型分布和抗菌药敏感性概况:一项横断面研究。

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES
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引用次数: 0

摘要

目标:印度尼西亚于 2022 年开始在全国范围内引入肺炎球菌结合疫苗 (PCV)。全国范围内肺炎链球菌的疫苗接种前数据对于未来疫苗效果评估至关重要。本研究评估了肺炎链球菌的定植流行率、与定植相关的因素、血清型分布和抗菌药敏感性概况:我们招募了儿童:我们收集了 499 份 NP 拭子标本。61.9%的儿童肺炎链球菌定植,48.9%的分离株为 PCV13 疫苗型。最常见的血清型为 23F、6B、19F 和 6A,分别占 13.2%、9.8%、8.9% 和 8.0%。暴露于香烟烟雾和流鼻涕是导致定植的重要风险因素,其aOR值分别为1.6(1.1 - 2.3)和2.1(1.4 - 3.3):本研究的结果可能有助于获得该国疫苗接种前的基线数据,这对疫苗影响评估至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence, serotype distribution, and antimicrobial susceptibility profile of Streptococcus pneumoniae in Sea Nomad children under 5 years of age in Wakatobi, Southeast Sulawesi, Indonesia: A cross-sectional study

Objective

Indonesia commenced the nationwide introduction of pneumococcal conjugate vaccine (PCV) in 2022. Pre-vaccine Streptococcus pneumoniae data from across the country could be critical to enable vaccine impact evaluation in the future. This study evaluates colonization prevalence, factors associated with colonization, serotype distribution, and the antimicrobial susceptibility profile of S. pneumoniae.

Methods

Children under 5 years of age were enrolled from Bajau tribe settlements in Wakatobi, southeast Sulawesi, Indonesia, from October 2018 to February 2019. Nasopharyngeal swab specimens were analysed by culture, and isolates were serotyped using sequential multiplex polymerase chain reaction. Antibiotic susceptibility was performed by the disk diffusion method. Multivariable logistic regression was performed for risk factor analysis.

Results

A total of 499 NP swab specimens were collected; 61.9% were colonized with S. pneumoniae and 48.9% of the isolates were of PCV13-vaccine type. The most common serotypes were 23F, 6B, 19F, and 6A at 13.2%, 9.8%, 8.9%, and 8.0%, respectively. Exposure to cigarette smoke in the household and runny nose were significant risk factors for colonization, with aORs of 1.6 (95% confidence interval: 1.1–2.3) and 2.1 (95% confidence interval: 1.4–3.3), respectively.

Conclusions

The findings of this study may contribute to baseline pre-vaccine data in Indonesia that would be critical for the impact evaluation of vaccines.

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来源期刊
Journal of global antimicrobial resistance
Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
8.70
自引率
2.20%
发文量
285
审稿时长
34 weeks
期刊介绍: The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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