CAR-NK 细胞疗法：克服肿瘤挑战的变革性方法。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-08-20 DOI:10.3390/biom14081035

Wangshu Li, Xiuying Wang, Xu Zhang, Aziz Ur Rehman Aziz, Daqing Wang

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引用次数: 0

摘要

在自然杀伤（NK）细胞中使用嵌合抗原受体（CAR）治疗癌症的势头日益强劲，标志着癌症治疗的重大转变。本综述旨在探索 CAR-NK 细胞疗法在癌症免疫疗法中的潜力，提供一个全新的视角。它讨论了 CAR-NK 细胞设计和工程中的创新方法，特别是针对难治性或复发性癌症的方法。通过比较CAR-NK细胞与传统疗法，综述强调了CAR-NK细胞应对肿瘤异质性和免疫系统抑制的独特能力。此外，它还解释了新型细胞因子和受体如何增强 CAR-NK 细胞的疗效、特异性和功能。这篇综述强调了 CAR-NK 细胞的优势，包括与 CAR-T 细胞相比毒性更低、成本更低、可及性更广，以及在治疗血癌和实体瘤方面的潜力。

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CAR-NK Cell Therapy: A Transformative Approach to Overcoming Oncological Challenges.

The use of chimeric antigen receptor (CAR) in natural killer (NK) cells for cancer therapy is gaining momentum, marking a significant shift in cancer treatment. This review aims to explore the potential of CAR-NK cell therapy in cancer immunotherapy, providing a fresh perspective. It discusses the innovative approaches in CAR-NK cell design and engineering, particularly targeting refractory or recurrent cancers. By comparing CAR-NK cells with traditional therapies, the review highlights their unique ability to tackle tumor heterogeneity and immune system suppression. Additionally, it explains how novel cytokines and receptors can enhance CAR-NK cell efficacy, specificity, and functionality. This review underscores the advantages of CAR-NK cells, including reduced toxicity, lower cost, and broader accessibility compared to CAR-T cells, along with their potential in treating both blood cancers and solid tumors.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.