植物合成基因组学：从小酵母中汲取大教训

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-10-17 DOI:10.1016/j.chembiol.2024.08.001

Hao Ye , Guangyu Luo , Zhenwu Zheng , Xiaofang Li , Jie Cao , Jia Liu , Junbiao Dai

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引用次数: 0

摘要

酵母因其遗传适应性而被广泛研究和改造。Sc2.0和Sc3.0等项目证明了构建合成酵母基因组的可行性，在研究和工业应用方面都取得了可喜的成果。相比之下，由于植物基因组的复杂性，植物合成基因组学一直面临挑战。不过，最近利用模式苔藓植物斑叶蕨藻（Physcomitrium patens）开展的 "SynMoss "项目取得的进展为植物合成基因组学提供了机遇。青苔和酵母的共同特点，如高同源重组率和显性单倍体生命周期，使研究人员能够对青苔基因组进行类似的操作，为植物合成生物学的研究和应用开辟了广阔的前景。总之，利用酵母合成基因组学的洞察力并将其应用于植物，以冬青树为突破口，显示出植物合成基因组学革命的巨大潜力。

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Plant synthetic genomics: Big lessons from the little yeast

Yeast has been extensively studied and engineered due to its genetic amenability. Projects like Sc2.0 and Sc3.0 have demonstrated the feasibility of constructing synthetic yeast genomes, yielding promising results in both research and industrial applications. In contrast, plant synthetic genomics has faced challenges due to the complexity of plant genomes. However, recent advancements of the project SynMoss, utilizing the model moss plant Physcomitrium patens, offer opportunities for plant synthetic genomics. The shared characteristics between P. patens and yeast, such as high homologous recombination rates and dominant haploid life cycle, enable researchers to manipulate P. patens genomes similarly, opening promising avenues for research and application in plant synthetic biology. In conclusion, harnessing insights from yeast synthetic genomics and applying them to plants, with P. patens as a breakthrough, shows great potential for revolutionizing plant synthetic genomics.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.