Application of Resonant Plasmonic Bowtie Nanoantennas for Optically‐Assisted Diffusiophoretic Trapping of Extracellular Vesicles and Nanoparticles

Plasmonic antennas leveraging localized surface plasmon resonances (LSPR) hold a significant premise for efficiently trapping nanoscale particles at low power levels. However, their effectiveness is hindered by photothermal effects that arise with metallic nanoparticles, leading to decreased stability of trapped particles. To address this limitation, a hybrid approach that combines depletion attraction and photothermal effects inherent in plasmonic structures is proposed, capitalizing on thermally induced concentration gradients. Through the thermophoretic depletion of polyethylene glycol (PEG) molecules around plasmonic hotspots, sharp concentration gradients are created, enabling precise localization of nanoscopic particles through a synergistic effect with diffusiophoretic forces. Our experiments successfully demonstrate the ability to trap and dynamically manipulate small extracellular vesicles and 100 nm polystyrene beads, showcasing the platform's potential for assembly at the nanoscale. Remarkably, this method maintains stable trapping performance even at a laser power of . The demonstration of stable trapping of small extracellular vesicles showcases the compatibility of this platform with bio species. This study introduces a promising avenue for the precise and efficient manipulation of nanoscale particles, with wide‐ranging implications in nanotechnology, biophysics, and nanomedicine. This research opens new opportunities for advancing nanoscale particle studies and applications, ushering in a new era of nanoscale manipulation techniques.