YAP/TAZ 机械信号在小梁网和 Schlemm 管细胞功能障碍中的作用

IF 1.5 4区心理学 Q4 NEUROSCIENCES

Vision Research Pub Date : 2024-08-28 DOI:10.1016/j.visres.2024.108477

Rajanya Ghosh , Samuel Herberg

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引用次数: 0

摘要

这篇重点综述强调了 "是 "相关蛋白（YAP）/具有 PDZ 结合基调的转录辅激活因子（TAZ）机械信号在人类小梁网和施莱姆管细胞中对青光眼相关细胞外基质硬化和周期性机械拉伸做出反应的重要性、以及生化通路调节剂（信号交叉），包括转化生长因子β2、糖皮质激素、Wnt、溶血磷脂酸、血管内皮生长因子和氧化应激。我们全面概述了过去十年的相关文献，重点介绍了具有转化潜力的有趣研究途径，最后展望了未来的研究方向。

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The role of YAP/TAZ mechanosignaling in trabecular meshwork and Schlemm’s canal cell dysfunction

This focused review highlights the importance of yes-associated protein (YAP)/transcriptional coactivator with PDZ binding motif (TAZ) mechanosignaling in human trabecular meshwork and Schlemm’s canal cells in response to glaucoma-associated extracellular matrix stiffening and cyclic mechanical stretch, as well as biochemical pathway modulators (with signaling crosstalk) including transforming growth factor beta 2, glucocorticoids, Wnt, lysophosphatidic acid, vascular endothelial growth factor, and oxidative stress. We provide a comprehensive overview of relevant literature from the last decade, highlight intriguing research avenues with translational potential, and close with an outlook on future directions.

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来源期刊

Vision Research 医学-神经科学

CiteScore

3.70

自引率

16.70%

发文量

111

审稿时长

66 days

期刊介绍： Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.