营养不良与感染：机制是什么？

IF 0.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Nutrition Clinique et Metabolisme Pub Date : 2024-08-08 DOI:10.1016/j.nupar.2024.06.001

Thomas Demangeat , Moïse Coëffier

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引用次数: 0

摘要

营养不良是一个重大的公共卫生问题，其特点是能量和营养平衡的改变，与感染并发症和死亡风险的增加有关。事实上，在许多研究中都有关于营养不良的受试者感染风险增加的报道。感染风险的增加涉及多种机制，包括免疫反应的改变和屏障功能的破坏，尤其是肠道屏障功能。在这篇简短的综述中，我们将重点关注营养不良情况下胸腺和脾脏的反应，以及能量燃料（即氨基酸和葡萄糖）的作用。此外，还讨论了维生素和微量元素的作用，以及肠道屏障功能的作用。

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Dénutrition et infections : quels mécanismes ?

Malnutrition, a major public health issue that characterized by an altered energetic and nutritional balance, is associated with an increase of infectious complications and mortality risk. Indeed, an increase of infectious risk has been reported in malnourished subjects in many studies. Various mechanisms are involved in the increased risk of infections and encompass an altered immune response and disrupted barrier function particularly gut barrier function. In this brief review, we focus on thymic and spleen response in malnourished conditions, as well as on the role of energetic fuels, i.e. amino acids, glucose. The contribution of vitamins and trace-elements is also discussed, as well as the role of gut barrier function.

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来源期刊

Nutrition Clinique et Metabolisme 医学-内分泌学与代谢

CiteScore

0.80

自引率

16.70%

发文量

216

审稿时长

78 days

期刊介绍： Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.