通过磁共振成像检测 COVID-19 幸存者的心脏重塑和炎症情况

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
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引用次数: 0

摘要

背景人们对COVID-19长期患者的心脏炎症,尤其是疾病急性期的心肌损伤表示担忧。本研究旨在通过心脏磁共振(CMR)成像检查 COVID-19 住院患者的心肌受累情况。所有患者出院后均被邀请接受 CMR 成像检查。在随访期间,首次 CMR 成像检查发现非缺血性心肌或心包受累的患者接受了第二次检查。将 CMR 成像检查结果与无合并症的健康患者对照组的结果进行了比较。平均年龄为 58.4 ± 18.3 岁,73.6% 为男性。43.4%和35.8%的患者出现心肌和心包LGE。非缺血性心肌或心包受累的患者有 26 例(49.1%)。心包LGE的发生率与出院和CMR之间的间隔时间成反比。与健康对照组相比,COVID-19 存活者的收缩末期容积指数 (ESVis) 较高,左心室射血分数较低。17名患者接受了随访CMR成像;舒张末期容积指数、ESVi和心包LGE的发生率降低了,但非缺血性LGE的发生率没有降低。结论 COVID-19幸存者在疾病急性期出现心肌损伤,非缺血性心肌和心包LGE以及CMR成像检测到的心脏重塑迹象的发生率很高,但在随访期间发生了部分逆转。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiac remodeling and inflammation detected by magnetic resonance imaging in COVID-19 survivors

Cardiac remodeling and inflammation detected by magnetic resonance imaging in COVID-19 survivors

Background

Concerns have been raised about cardiac inflammation in patients with long COVID-19, particularly those with myocardial injury during the acute phase of the disease. This study was conducted to examine myopericardial involvement, detected by cardiac magnetic resonance (CMR) imaging in patients hospitalized for COVID-19.

Methods

Adult patients hospitalized with COVID-19 who presented myocardial injury or increased D-dimers were enrolled in this prospective study. All patients were invited to undergo CMR imaging examination after discharge. During follow-up, patients with nonischemic myocardial or pericardial involvement detected on the first CMR imaging examination underwent second examinations. CMR imaging findings were compared with those of a control group of healthy patients with no comorbidity.

Results

Of 180 included patients, 53 underwent CMR imaging examination. The mean age was 58.4 ± 18.3 years, and 73.6 % were male. Myocardial and pericardial LGE was reported in 43.4 % and 35.8 % of patients, respectively. Nonischemic myocardial or pericardial involvement was reported in 26 (49.1 %) patients. The prevalence of pericardial LGE was associated inversely with the interval between hospital discharge and CMR. COVID-19 survivors had higher end-systolic volume indices (ESVis) and lower left-ventricular ejection fractions than did healthy controls. Seventeen patients underwent follow-up CMR imaging; the end-diastolic volume index, ESVi, and prevalence of pericardial LGE, but not that of nonischemic LGE, were reduced.

Conclusion

Among COVID-19 survivors with myocardial injury during the acute phase of the disease, the incidences of nonischemic myocardial and pericardial LGE and CMR imaging–detected signs of cardiac remodeling, partially reversed during follow-up, were high.

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来源期刊
IJC Heart and Vasculature
IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine
CiteScore
4.90
自引率
10.30%
发文量
216
审稿时长
56 days
期刊介绍: IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.
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