{"title":"山奈酚对掺有真空瓦斯油的嘎啦粉引起的肾毒性和神经毒性的影响","authors":"Joel Okpoghono , Busade Adebayo Agbetuyi , Toritseju Eyide , Innocent Onyesom","doi":"10.1016/j.focha.2024.100794","DOIUrl":null,"url":null,"abstract":"<div><p>The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (<em>n</em> = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na<sup>+</sup>/K<sup>+</sup>-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats.</p></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"5 ","pages":"Article 100794"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772753X24001898/pdfft?md5=894cdeb5ec6ee114f9c3e35fb2c94f07&pid=1-s2.0-S2772753X24001898-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity\",\"authors\":\"Joel Okpoghono , Busade Adebayo Agbetuyi , Toritseju Eyide , Innocent Onyesom\",\"doi\":\"10.1016/j.focha.2024.100794\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (<em>n</em> = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na<sup>+</sup>/K<sup>+</sup>-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats.</p></div>\",\"PeriodicalId\":73040,\"journal\":{\"name\":\"Food chemistry advances\",\"volume\":\"5 \",\"pages\":\"Article 100794\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772753X24001898/pdfft?md5=894cdeb5ec6ee114f9c3e35fb2c94f07&pid=1-s2.0-S2772753X24001898-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food chemistry advances\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772753X24001898\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food chemistry advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772753X24001898","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of kaempferol against garri meal tainted with vacuum gas oil induced nephro- and neurotoxicity
The present study investigated the defensive effect of kaempferol in the tissues of Wistar rats fed with vacuum gas oil polluted garri diet. The rats (30) were grouped into six (n = 5): Group 1: Control: Fried garri normal diet (FGND). Group 2 and 3 were given FGND and treated with 50 and 100 mg/kg b. wt of kaempferol. Group 4: Fried garri diet with vacuum gas oil (FGD-VGO) only. Group 5 and 6 were given FGD-VGO then treated with 50 and 100 mg/kg b. wt. of kaempferol. The rats were euthanized using carbon dioxide after experimental period of 28 days. The tissues (kidney and brain) were excised for biochemical assays. The results indicated a significant decrease in antioxidant markers (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-s-transferase, GST), Na+/K+-ATPase, percentage of fragmented deoxyribonucleic acid (DNA) and increase malondialdehyde (MDA) in the tissues of rats in group 4 compared to the other groups. However, treatment with kaempferol significantly decreased MDA level and increased antioxidant markers in the tissues of rats fed FGD-VGO. In conclusion, the data obtained may point out to kaempferol playing a crucial role as an antioxidant against garri meal tainted with vacuum gas oil in Wistar rats.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
