高流量鼻插管和双水平气道正压疗法作为呼吸理疗干预措施对哮喘加重儿童的效果比较:随机临床试验。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Einstein-Sao Paulo Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.31744/einstein_journal/2024AO0588
Maisi Muniz Cabral David, Evelim Leal de Freitas Dantas Gomes, Carla Lima Feitoza Cavassini, Josiane Germano Luiz, Dirceu Costa
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引用次数: 0

摘要

目的:高流量鼻插管是一种实用、安全的工具,可用于哮喘加重的儿童,并能促进改善哮喘严重程度评分、缩短住院时间、减少沙丁胺醇用量和氧气用量等有益结果。目的:评估和比较高流量鼻插管治疗和双水平气道正压治疗作为呼吸理疗干预措施对因哮喘加重而住院的儿童患者的疗效:在一项随机临床试验中,使用高流量鼻插管和双水平气道正压对住院的哮喘患儿进行了治疗。随机分组后,收集有关肺功能、生命体征和严重程度评分(肺指数、小儿哮喘严重程度和小儿哮喘评分)的数据:本研究共纳入了 50 名患者(25 名在双水平组,25 名在高流量鼻插管组)。治疗 45 分钟后,1 秒钟用力呼气量有所改善。与 Bilevel 组相比,高流量鼻插管组需要使用氧气(O2)的天数更少,使用的支气管扩张剂(沙丁胺醇吸入量)更少,住院时间更短(6.1±1.9 天对 4.3±1.3 天;95% 置信区间,-5.0 到 -0.6):高流量鼻插管是治疗哮喘加重的可行方案,因为它可以缩短住院时间,减少对氧气和支气管扩张剂的需求。此外,它还是一种安全舒适的治疗方式,与双水平气道正压一样有效:NCT04033666。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the effects of high-flow nasal cannula and bilevel positive airway pressure treatments as respiratory physiotherapy interventions for children with asthma exacerbation: a randomized clinical trial.

Objective: A high-flow nasal cannula is a practical and safe instrument that can be used for children with asthma exacerbation and promotes beneficial outcomes such as improved asthma severity scores and reduced hospitalization durations, salbutamol use, and oxygen use. To evaluate and compare the efficacy of high-flow nasal cannula treatment and that of bilevel positive airway pressure treatment as respiratory physiotherapy interventions for pediatric patients who are hospitalized because of asthma exacerbation.

Methods: During a randomized clinical trial, treatment was performed using a high-flow nasal cannula and bilevel positive airway pressure for hospitalized children with asthma. After randomization, data regarding lung function, vital signs, and severity scores (pulmonary index, pediatric asthma severity, and pediatric asthma scores) were collected.

Results: Fifty patients were included in this study (25 in the Bilevel Group and 25 in the high-flow nasal cannula group). After 45 minutes of therapy, an improvement in the forced expiratory volume in 1 second was observed. The high-flow nasal cannula group required fewer days of oxygen (O2) use, used fewer bronchodilators (number of salbutamol puffs), and required shorter hospitalization periods than the Bilevel Group (6.1±1.9 versus 4.3±1.3 days; 95% confidence interval, -5.0 to -0.6).

Conclusion: A high-flow nasal cannula is a viable option for the treatment of asthma exacerbation because it can reduce the hospitalization period and the need for O2 and bronchodilators. Additionally, it is a safe and comfortable treatment modality that is as effective as bilevel positive airway pressure.ClinicalTrials.gov Identifier: NCT04033666.

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来源期刊
Einstein-Sao Paulo
Einstein-Sao Paulo MEDICINE, GENERAL & INTERNAL-
CiteScore
2.00
自引率
0.00%
发文量
210
审稿时长
38 weeks
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