甲状腺自身抗体与甲状腺乳头状癌侵袭性特征的关系:一项病例对照研究。

IF 2.5 3区 医学 Q3 ONCOLOGY
Hai-Long Tan, Zi-En Qin, Sai-Li Duan, Ya-Ling Jiang, Neng Tang, Shi Chang
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引用次数: 0

摘要

目的:尽管自身免疫性甲状腺炎与甲状腺乳头状癌(PTC)之间的潜在关联已得到认可,但PTC的临床病理特征是否会受到甲状腺自身抗体的影响仍是未知数:我们对中国中部省份3个医疗中心的15305名患者(包括11465名女性和3840名男性)进行了病例对照研究,探讨甲状腺自身抗体与PTC临床病理特征的相关性。采用逻辑回归和限制性立方样条模型分析甲状腺自身抗体与PTC临床病理特征的关系:在15305名参与研究的患者中,有10087人(65.9%)的甲状腺自身抗体呈阴性,5218人(34.1%)的甲状腺自身抗体呈阳性。其中,1,530人(10.0%)仅TPOAb呈阳性,1,247人(8.2%)仅TGAb呈阳性,另有2,441人(15.9%)表现出TPOAb和TGAb双重阳性。甲状腺自身抗体水平与 PTC 的某些侵袭性特征有显著相关性。具体来说,TGAb水平与多灶性、双侧肿瘤、甲状腺外扩展、淋巴结转移以及受累淋巴结超过5个的可能性增加直接相关。然而,TPOAb水平与甲状腺外扩展、淋巴结转移和超过5个受累淋巴结的相关风险呈反向关系:结论:TGAb水平升高与PTC侵袭性特征的风险呈正相关,而TPOAb水平高与甲状腺外扩展和淋巴结转移的风险呈反相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of thyroid autoantibodies with aggressive characteristics of papillary thyroid cancer: a case-control study.

Purpose: Although the potential association between autoimmune thyroiditis and papillary thyroid cancer (PTC) has been acknowledged, whether the clinicopathological features of PTC will be affected by thyroid autoantibodies remains unknown.

Patients and methods: We conducted a case-control study to investigate the association of thyroid autoantibodies with clinicopathological characteristics of PTC in 15,305 patients (including 11,465 females and 3,840 males) from 3 medical centers in the central province of China. Logistic regression and restricted cubic spline models were performed to analyze the association of thyroid autoantibodies with clinicopathological features of PTC.

Results: In total, out of the 15,305 patients enrolled in this study, 10,087 (65.9%) had negative thyroid autoantibodies, while 5,218(34.1%) tested positive thyroid autoantibodies. Among these individuals, 1,530(10.0%) showed positivity for TPOAb only, 1,247(8.2%) for TGAb only and a further 2,441(15.9%) exhibited dual positivity for both TPOAb and TGAb combined. Thyroid autoantibodies level demonstrated significant correlations with certain aggressive features in PTC. Specifically, TGAb level displayed a direct correlation to an increased likelihood of multifocality, bilateral tumor, extrathyroidal extension, lymph node metastasis, as well as more than five affected lymph nodes. However, TPOAb level exhibited an inverse association with the risk associated with extrathyroidal extension, lymph node metastasis, and more than five affected lymph nodes.

Conclusion: Elevated level of TGAb were positively correlated with the risk of aggressive features in PTC, while high level of TPOAb were inversely associated with the risk of extrathyroidal extension and lymph node metastasis.

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来源期刊
CiteScore
4.70
自引率
15.60%
发文量
362
审稿时长
3 months
期刊介绍: World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
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