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引用次数: 0
摘要
在本期《世界胃肠病学杂志》(World Journal of Gastroenterology)上,Huang 等人报道了传统中药牛黄(CB)能在体内阻碍肝癌的生长。通过进一步的体外研究,他们发现牛黄通过抑制 Wnt 信号通路,抑制了肿瘤相关巨噬细胞的 M2 极化,从而抑制了肝癌的生长。虽然传统中草药的作用往往没有科学依据,但Huang等人成功鉴定了CB抗癌作用的分子机制,预计其他传统中草药的作用分子机制也将如本文所示得到科学阐明。
Unveiling the anticancer effect of traditional Chinese herbal medicine.
In this issue of World Journal of Gastroenterology, Huang et al reported that Calculus bovis (CB), a traditional Chinese herbal medicine, impedes the growth of liver cancers in vivo. Through further in vitro studies, they showed that CB suppressed the M2 polarization of tumor-associated macrophages by suppressing the Wnt signaling pathway, which consequently inhibited the growth of liver cancer. Although the effects of traditional Chinese herbal medicine are often not scientifically proven, Huang et al successfully identified the molecular mechanism involved in the anticancer effect of CB, and it is anticipated that the molecular mechanisms involved in the effects of other traditional Chinese herbal medicines will be scientifically elucidated, as demonstrated in this article.
期刊介绍:
The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.