Julie Semenchuk , Yumi Naito , Susan C. Charman , Siobhán B Carr , Stephanie Y. Cheng , Bruce C. Marshall , Albert Faro , Alexander Elbert , Hector H. Gutierrez , Christopher H. Goss , Bulent Karadag , Pierre-Régis Burgel , Carla Colombo , Marco Salvatore , Rita Padoan , Géraldine Daneau , Satenik Harutyunyan , Nataliya Kashirskaya , Laura Kirwan , Peter G Middleton , Rebecca Cosgriff
{"title":"COVID-19 感染对囊性纤维化患者肺功能和营养状况的影响：全球队列研究。","authors":"Julie Semenchuk , Yumi Naito , Susan C. Charman , Siobhán B Carr , Stephanie Y. Cheng , Bruce C. Marshall , Albert Faro , Alexander Elbert , Hector H. Gutierrez , Christopher H. Goss , Bulent Karadag , Pierre-Régis Burgel , Carla Colombo , Marco Salvatore , Rita Padoan , Géraldine Daneau , Satenik Harutyunyan , Nataliya Kashirskaya , Laura Kirwan , Peter G Middleton , Rebecca Cosgriff","doi":"10.1016/j.jcf.2024.07.019","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).</p></div><div><h3>Methods</h3><p>This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV<sub>1</sub>) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV<sub>1</sub> and BMI were compared using a <em>t</em>-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.</p></div><div><h3>Results</h3><p>A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV<sub>1</sub> pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (<em>p</em> = 0.24) and -0.74 % (-1.89, 0.41) per year (<em>p</em> = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.</p></div><div><h3>Conclusions</h3><p>No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.</p></div>","PeriodicalId":15452,"journal":{"name":"Journal of Cystic Fibrosis","volume":"23 5","pages":"Pages 815-822"},"PeriodicalIF":5.4000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S156919932400804X/pdfft?md5=31a1e8960a5b2129cfb928307604f1eb&pid=1-s2.0-S156919932400804X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study\",\"authors\":\"Julie Semenchuk , Yumi Naito , Susan C. Charman , Siobhán B Carr , Stephanie Y. Cheng , Bruce C. Marshall , Albert Faro , Alexander Elbert , Hector H. Gutierrez , Christopher H. Goss , Bulent Karadag , Pierre-Régis Burgel , Carla Colombo , Marco Salvatore , Rita Padoan , Géraldine Daneau , Satenik Harutyunyan , Nataliya Kashirskaya , Laura Kirwan , Peter G Middleton , Rebecca Cosgriff\",\"doi\":\"10.1016/j.jcf.2024.07.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).</p></div><div><h3>Methods</h3><p>This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV<sub>1</sub>) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV<sub>1</sub> and BMI were compared using a <em>t</em>-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.</p></div><div><h3>Results</h3><p>A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV<sub>1</sub> pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (<em>p</em> = 0.24) and -0.74 % (-1.89, 0.41) per year (<em>p</em> = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.</p></div><div><h3>Conclusions</h3><p>No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.</p></div>\",\"PeriodicalId\":15452,\"journal\":{\"name\":\"Journal of Cystic Fibrosis\",\"volume\":\"23 5\",\"pages\":\"Pages 815-822\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S156919932400804X/pdfft?md5=31a1e8960a5b2129cfb928307604f1eb&pid=1-s2.0-S156919932400804X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cystic Fibrosis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S156919932400804X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cystic Fibrosis","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156919932400804X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
Background
Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
Methods
This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.
Results
A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.
Conclusions
No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.
期刊介绍：
The Journal of Cystic Fibrosis is the official journal of the European Cystic Fibrosis Society. The journal is devoted to promoting the research and treatment of cystic fibrosis. To this end the journal publishes original scientific articles, editorials, case reports, short communications and other information relevant to cystic fibrosis. The journal also publishes news and articles concerning the activities and policies of the ECFS as well as those of other societies related the ECFS.
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