人工动脉栓塞模型中凝胶参数对透明质酸凝胶填充物分散和碎裂的影响

IF 5 3区 化学 Q1 POLYMER SCIENCE
Gels Pub Date : 2024-08-12 DOI:10.3390/gels10080530
Danny J Soares, Alec D McCarthy
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引用次数: 0

摘要

透明质酸(HA)填充物意外动脉栓塞可导致严重的并发症,包括皮肤缺血、失明和中风。目前,HA 凝胶在动脉内的分散和破碎行为尚不清楚,但对我们了解这些损伤的病理机制至关重要。这项研究引入了动脉栓塞限制实验室模拟脉冲装置(PULSAR),并评估了不同医管局凝胶的血管内行为。通过高分辨率摄像和ImageJ粒度与形态分析,评估了四种具有不同流变特性的HA凝胶的破碎和分散行为。随后将凝胶的弹性模量(G')、损耗模量(G″)、tan(δ)和 HA 浓度与其动脉内行为相关联。这项研究有效证实了 HA 凝胶在动脉接种后会发生广泛的碎裂,颗粒大小从 1 毫米不等。凝胶颗粒大小和形态与 tan(δ) 的相关性最大。相反,虽然近端大血管阻塞的概率受到影响,但动脉流速对凝胶破碎行为并无明显影响。总之,这项研究验证了 PULSAR 模型在模拟动脉动力学和测试血管内填充物运动学方面的有效性。研究结果表明,凝胶具有微碎裂和向远端扩散的能力,并能根据凝胶流变学和动脉流动参数诱发部分近端闭塞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers within an Artificial Model of Arterial Embolism.

Accidental arterial embolization of hyaluronic acid (HA) fillers can lead to severe complications, including skin ischemia, blindness, and stroke. Currently, the intra-arterial dispersal and fragmentation behavior of HA gels is unknown but critical to our understanding of the pathomechanism of these injuries. This work introduces the Pulsatile Unit for the Laboratory Simulation of Arterio-embolic Restrictions (PULSAR) and evaluates the intravascular behavior of different HA gels. The fragmentation and dispersal behaviors of four HA gels with distinct rheological properties were evaluated via high-resolution videography and ImageJ particle size and morphology analysis. The gels' elastic modulus (G'), loss modulus (G″), tan(δ), and HA concentration were subsequently correlated with their intra-arterial behaviors. This study effectively confirms the extensive fragmentation of HA gels upon arterial inoculation, with particle sizes ranging from <50 µm to >1 mm. Gel particle size and morphology correlated most significantly with tan(δ). Conversely, arterial flow rates did not significantly influence gel fragmentation behavior, though the probability of proximal, macrovascular obstruction was affected. Overall, this study validates the PULSAR model for simulation of arterial dynamics and the testing of intravascular filler kinematics. The findings demonstrate the ability of gels to microfragment and disseminate distally, as well as induce partial proximal occlusion depending on gel rheology and arterial flow parameters.

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来源期刊
Gels
Gels POLYMER SCIENCE-
CiteScore
4.70
自引率
19.60%
发文量
707
审稿时长
11 weeks
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