曲哈洛糖通过激活自噬和改善线粒体质量来缓解睾丸衰老。

IF 3.2 2区 医学 Q1 ANDROLOGY
Andrology Pub Date : 2024-08-28 DOI:10.1111/andr.13746
Huaming Xi, Wenjing Shan, Minghui Li, Ziqian Wang, Yuan Li
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引用次数: 0

摘要

背景:生殖衰老会对男性的生育能力和后代的健康产生不利影响。衰老过程伴随着自噬功能受损。最近的研究表明,曲哈洛糖通过调节自噬在预防各种疾病方面发挥着重要作用。然而,曲哈洛糖在睾丸衰老和生殖能力衰退中的作用仍有待明确:本研究旨在评估在衰老小鼠模型中曲哈洛糖对睾丸的保护作用:本研究通过给小鼠注射 D-半乳糖建立了一个体内衰老模型,以探讨曲哈洛糖对睾丸衰老的保护作用。我们检测了组织学变化以及细胞凋亡、自噬、线粒体生物生成和精子质量的相关指标:结果:D-半乳糖处理可诱导小鼠睾丸细胞氧化应激、凋亡和自噬功能受损。服用曲哈洛糖能明显减少D-半乳糖诱导的氧化应激引起的生殖细胞凋亡和DNA损伤。值得注意的是,曲哈洛糖激活了睾丸细胞的自噬活性并改善了线粒体功能。此外,曲哈洛糖还能提高紧密连接蛋白 ZO-1 的表达水平,加速清除 Sertoli 细胞中受损的线粒体,这表明曲哈洛糖能改善 D-半乳糖诱导的老化睾丸中 Sertoli 细胞的功能:这些研究结果表明,服用曲哈洛糖能激活睾丸细胞的自噬活性,改善线粒体功能,从而有效防止睾丸衰老。因此,通过服用曲哈洛糖恢复自噬活性可能是一种延缓衰老的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.

Background: Reproductive aging can adversely affect male fertility and the health of offspring. The aging process is accompanied by impaired autophagy. Recent studies have shown that Trehalose plays an important role in the prevention of various diseases by regulating autophagy. However, the roles of Trehalose in testicular aging and reproductive decline remain to be clarified.

Objective: The present study aimed to evaluate the protective effects of Trehalose on testes in an aging mouse model.

Materials and methods: In this study, an in vivo aging model in mice by administering D-galactose was established to explore the protective effect of Trehalose on testicular aging. We examined histological changes and related indicators of apoptosis, autophagy, mitochondrial biogenesis, and sperm quality.

Results: D-galactose treatment induced oxidative stress, apoptosis, and impairment of autophagy of testicular cells in mouse testes. Trehalose administration significantly reduced germ cell apoptosis and DNA damage caused by D-galactose-induced oxidative stress. Notably, Trehalose activated autophagy activity and improved mitochondrial function in testicular cells. Furthermore, Trehalose treatment increased the expression level of the tight junction protein ZO-1, and accelerated clearance of damaged mitochondria in Sertoli cells, indicating that Trehalose ameliorated Sertoli cell function in D-galactose-induced aging testes.

Discussion and conclusion: These findings suggest that Trehalose administration activated the autophagy activity in testicular cells and improved mitochondrial function, thereby effectively preventing testicular aging. Trehalose and its activated autophagy are crucial for preventing testicular aging, thus restoring autophagy activity by administering Trehalose could be a promising means to delay aging.

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来源期刊
Andrology
Andrology ANDROLOGY-
CiteScore
9.10
自引率
6.70%
发文量
200
期刊介绍: Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology
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