单细胞测序技术在卵巢癌研究中的应用（综述）。

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2024-08-28 DOI:10.1007/s10142-024-01432-w

Qiqolei Yuan, Nengyuan Lv, Qianying Chen, Siyi Shen, Yahui Wang, Jinyi Tong

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引用次数: 0

摘要

卵巢癌是一种卵巢恶性肿瘤。它具有早期诊断难、晚期疗效差、复发率高等特点。它是严重威胁妇女健康的最大疾病。单细胞测序技术是指在单细胞水平上对其携带的遗传信息进行测序，获得某一细胞类型的基因序列、转录本、蛋白质和表观遗传表达谱信息，并进行综合分析。它在研究肿瘤的发生和演化方面具有独特的优势，可为卵巢癌的研究提供新的方法。本文综述了单细胞测序技术及其在卵巢癌中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Application of single cell sequencing technology in ovarian cancer research (review)

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Application of single cell sequencing technology in ovarian cancer research (review)

Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that seriously threatens women’s health. Single cell sequencing technology refers to sequencing the genetic information carried by it at the single cell level to obtain the gene sequence, transcript, protein and epigenetic expression profile information of a certain cell type and conduct integrated analysis. It has unique advantages in the study of tumor occurrence and evolution, and can provide new methods for the study of ovarian cancer. This paper reviews the single cell sequencing technology and its application in ovarian cancer.

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?