Rami Gabani, Salvatore Brugaletta, Kamil Bujak, María José Pèrez-Vizcayno, Pilar Jiménez-Quevedo, Víctor Arévalos, Erika Muñoz-García, Ramiro Trillo-Nouche, Raquel Del Valle, José M de la Torre Hernández, Luisa Salido, Enrique Gutiérrez, Manuel Pan, Joaquín Sánchez-Gila, Bruno García Del Blanco, Raúl Moreno, Roberto Blanco Mata, Juan Francisco Oteo, Ignacio Amat-Santos, Ander Regueiro, Francisco Ten, Juan Manuel Nogales, Eduard Fernández-Nofrerías, Leire Andraka, María Cruz Ferrer, Eduardo Pinar, Rafael Romaguera, Carlos Cuellas Ramón, Fernando Alfonso, Sergio García-Blas, Antonio Piñero, Julia Ignasi, Rocío Díaz Mèndez, Pascual Bordes, Juan Meseguer, Luis Nombela-Franco, Manel Sabaté
{"title":"经导管主动脉瓣植入术后性别对院内和长期预后的影响：西班牙 TAVI 登记分析。","authors":"Rami Gabani, Salvatore Brugaletta, Kamil Bujak, María José Pèrez-Vizcayno, Pilar Jiménez-Quevedo, Víctor Arévalos, Erika Muñoz-García, Ramiro Trillo-Nouche, Raquel Del Valle, José M de la Torre Hernández, Luisa Salido, Enrique Gutiérrez, Manuel Pan, Joaquín Sánchez-Gila, Bruno García Del Blanco, Raúl Moreno, Roberto Blanco Mata, Juan Francisco Oteo, Ignacio Amat-Santos, Ander Regueiro, Francisco Ten, Juan Manuel Nogales, Eduard Fernández-Nofrerías, Leire Andraka, María Cruz Ferrer, Eduardo Pinar, Rafael Romaguera, Carlos Cuellas Ramón, Fernando Alfonso, Sergio García-Blas, Antonio Piñero, Julia Ignasi, Rocío Díaz Mèndez, Pascual Bordes, Juan Meseguer, Luis Nombela-Franco, Manel Sabaté","doi":"10.1016/j.rec.2024.08.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Impact of gender on long-term outcomes after transcatheter aortic valve implantation (TAVI) remains uncertain. We aimed to investigate gender-specific differences in TAVI and its impact on outcomes.</p><p><strong>Methods: </strong>This analysis used data from the prospective Spanish TAVI registry, which included consecutive TAVI patients treated in 46 Spanish centers from 2009 to 2021. The primary endpoint was all-cause mortality at 12 months. Secondary endpoints included in-hospital and 30-day mortality and TAVI-related complications. Adjusted logistic and Cox regression analyses were performed.</p><p><strong>Results: </strong>The study included 12 253 consecutive TAVI patients with a mean age of 81.2±6.4 years. Women (53.9%) were older, and had a higher STS-PROM score (7.0±7.0 vs 6.2±6.7; P < .001) than men. Overall, the TAVI-related complication rate was similar between women and men, with specific gender-related complications. While women more frequently developed in-hospital vascular complications (13.6% vs 9.8%; P <.001) and cardiac tamponade (1.5% vs 0.6%; P=.009), men showed a higher incidence of permanent pacemaker implantation (14.5% vs 17.4%; P=.009). There was no difference in all-cause mortality either in hospital (3.6% vs 3.6%, adjusted OR, 1.01; 95%CI, 0.83-1.23; P=.902), at 30 days (4.2% vs 4.2%, adjusted OR, 0.90; 95%CI, 0.65-1.25; P=.564) or at 1 year (11% vs 13%, adjusted HR, 0.94; 95%CI, 0.80-1.11; P=.60).</p><p><strong>Conclusions: </strong>Women treated with TAVI are older and have more comorbidities than men, leading to distinct complications between genders. Nevertheless, all-cause mortality in the short-term and at 1-year was similar between men and women.</p>","PeriodicalId":38430,"journal":{"name":"Revista española de cardiología (English ed.)","volume":null,"pages":null},"PeriodicalIF":7.2000,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of gender on in-hospital and long-term outcomes after transcatheter aortic valve implantation: an analysis of the Spanish TAVI registry.\",\"authors\":\"Rami Gabani, Salvatore Brugaletta, Kamil Bujak, María José Pèrez-Vizcayno, Pilar Jiménez-Quevedo, Víctor Arévalos, Erika Muñoz-García, Ramiro Trillo-Nouche, Raquel Del Valle, José M de la Torre Hernández, Luisa Salido, Enrique Gutiérrez, Manuel Pan, Joaquín Sánchez-Gila, Bruno García Del Blanco, Raúl Moreno, Roberto Blanco Mata, Juan Francisco Oteo, Ignacio Amat-Santos, Ander Regueiro, Francisco Ten, Juan Manuel Nogales, Eduard Fernández-Nofrerías, Leire Andraka, María Cruz Ferrer, Eduardo Pinar, Rafael Romaguera, Carlos Cuellas Ramón, Fernando Alfonso, Sergio García-Blas, Antonio Piñero, Julia Ignasi, Rocío Díaz Mèndez, Pascual Bordes, Juan Meseguer, Luis Nombela-Franco, Manel Sabaté\",\"doi\":\"10.1016/j.rec.2024.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction and objectives: </strong>Impact of gender on long-term outcomes after transcatheter aortic valve implantation (TAVI) remains uncertain. We aimed to investigate gender-specific differences in TAVI and its impact on outcomes.</p><p><strong>Methods: </strong>This analysis used data from the prospective Spanish TAVI registry, which included consecutive TAVI patients treated in 46 Spanish centers from 2009 to 2021. The primary endpoint was all-cause mortality at 12 months. Secondary endpoints included in-hospital and 30-day mortality and TAVI-related complications. Adjusted logistic and Cox regression analyses were performed.</p><p><strong>Results: </strong>The study included 12 253 consecutive TAVI patients with a mean age of 81.2±6.4 years. Women (53.9%) were older, and had a higher STS-PROM score (7.0±7.0 vs 6.2±6.7; P < .001) than men. Overall, the TAVI-related complication rate was similar between women and men, with specific gender-related complications. While women more frequently developed in-hospital vascular complications (13.6% vs 9.8%; P <.001) and cardiac tamponade (1.5% vs 0.6%; P=.009), men showed a higher incidence of permanent pacemaker implantation (14.5% vs 17.4%; P=.009). There was no difference in all-cause mortality either in hospital (3.6% vs 3.6%, adjusted OR, 1.01; 95%CI, 0.83-1.23; P=.902), at 30 days (4.2% vs 4.2%, adjusted OR, 0.90; 95%CI, 0.65-1.25; P=.564) or at 1 year (11% vs 13%, adjusted HR, 0.94; 95%CI, 0.80-1.11; P=.60).</p><p><strong>Conclusions: </strong>Women treated with TAVI are older and have more comorbidities than men, leading to distinct complications between genders. Nevertheless, all-cause mortality in the short-term and at 1-year was similar between men and women.</p>\",\"PeriodicalId\":38430,\"journal\":{\"name\":\"Revista española de cardiología (English ed.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":7.2000,\"publicationDate\":\"2024-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista española de cardiología (English ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.rec.2024.08.002\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista española de cardiología (English ed.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.rec.2024.08.002","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Impact of gender on in-hospital and long-term outcomes after transcatheter aortic valve implantation: an analysis of the Spanish TAVI registry.
Introduction and objectives: Impact of gender on long-term outcomes after transcatheter aortic valve implantation (TAVI) remains uncertain. We aimed to investigate gender-specific differences in TAVI and its impact on outcomes.
Methods: This analysis used data from the prospective Spanish TAVI registry, which included consecutive TAVI patients treated in 46 Spanish centers from 2009 to 2021. The primary endpoint was all-cause mortality at 12 months. Secondary endpoints included in-hospital and 30-day mortality and TAVI-related complications. Adjusted logistic and Cox regression analyses were performed.
Results: The study included 12 253 consecutive TAVI patients with a mean age of 81.2±6.4 years. Women (53.9%) were older, and had a higher STS-PROM score (7.0±7.0 vs 6.2±6.7; P < .001) than men. Overall, the TAVI-related complication rate was similar between women and men, with specific gender-related complications. While women more frequently developed in-hospital vascular complications (13.6% vs 9.8%; P <.001) and cardiac tamponade (1.5% vs 0.6%; P=.009), men showed a higher incidence of permanent pacemaker implantation (14.5% vs 17.4%; P=.009). There was no difference in all-cause mortality either in hospital (3.6% vs 3.6%, adjusted OR, 1.01; 95%CI, 0.83-1.23; P=.902), at 30 days (4.2% vs 4.2%, adjusted OR, 0.90; 95%CI, 0.65-1.25; P=.564) or at 1 year (11% vs 13%, adjusted HR, 0.94; 95%CI, 0.80-1.11; P=.60).
Conclusions: Women treated with TAVI are older and have more comorbidities than men, leading to distinct complications between genders. Nevertheless, all-cause mortality in the short-term and at 1-year was similar between men and women.
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