探索渗出物的粘度:伤口渗出物流变分析。

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI:10.1111/wrr.13213
Gianluca Melotto, Avick Sinha, Jaqueline Rachel Forss
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引用次数: 0

摘要

渗出物及其粘度对伤口愈合至关重要。粘度的变化会干扰敷料的特性,并影响免疫细胞、营养物质、氧气和细菌的扩散。目前实验室测试伤口敷料的国际标准使用的是单一的低粘度溶液,即 "测试溶液 A",这种溶液无法模拟临床上遇到的各种渗出液。本研究采用流变学分析来描述渗出液的粘度特性,并将牛源样本与测试溶液 A 进行比较。结果显示渗出液具有非牛顿、剪切稀化特性,与测试溶液 A 的牛顿特性形成鲜明对比。虽然临床上将渗出液归类为 "血清脓性",但在 37°C 温度下分析的三个渗出液样本在不同剪切速率下具有不同的粘度,从 30.8 (±14.7) 到 6.5 (±1.9) mPas 不等。研究结果表明,目前使用测试溶液 A 对敷料进行的测试未能反映真实渗出物的复杂性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring exudate viscosity: A rheological analysis of wound exudates.

Exudate and its viscosity are critical in wound healing. Changes in viscosity can interfere with dressings properties as well as affect the diffusion of immune cells, nutrients, oxygen and bacteria. Current international standards for laboratory testing of wound dressings use a single low-viscosity solution, named as 'Test Solution A', which fails to simulate the diverse range of exudates encountered clinically. This study employs rheological analysis to characterise exudates viscosity, comparing cattle-derived samples to the test solution A. Results reveal non-Newtonian, shear-thinning behaviour in exudates, contrasting with the Newtonian behaviour of the test solution A. Although clinically classified as 'seropurulent', three exudate samples analysed at 37°C present with different viscosity at various shear rates, ranging from 30.8 (±14.7) to 6.5 (±1.9) mPas. Findings show that the current tests on dressings employing Test Solution A are missing the complexity of real exudates.

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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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