用于发现抗癌抗体的噬菌体展示。

IF 4.5 2区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

New biotechnology Pub Date : 2024-08-24 DOI:10.1016/j.nbt.2024.08.506

Polina V. Istomina , Andrey A. Gorchakov , Chatchanok Paoin , Montarop Yamabhai

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引用次数: 0

摘要

抗体和基于抗体的免疫疗法是癌症免疫疗法的支柱。扩大可使用抗体靶向的癌症特异性和癌症相关表位库是一个重要的研究领域。噬菌体展示是一种功能强大的方法，可利用不同的抗体库筛选出与各种靶点结合的抗体。在这篇综述中，我们总结了噬菌体展示技术的基本原理，并重点介绍了通过噬菌体展示平台鉴定和修饰抗癌抗体的进展。最后，我们介绍了噬菌体展示衍生的抗癌单克隆抗体，这些抗体目前已经获得批准或正在进行临床开发。

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Phage display for discovery of anticancer antibodies

Antibodies and antibody-based immunotherapeutics are the mainstays of cancer immunotherapy. Expanding the repertoire of cancer-specific and cancer-associated epitopes targetable with antibodies represents an important area of research. Phage display is a powerful approach allowing the use of diverse antibody libraries to be screened for binding to a wide range of targets. In this review, we summarize the basics of phage display technology and highlight the advances in anticancer antibody identification and modification via phage display platform. Finally, we describe phage display-derived anticancer monoclonal antibodies that have been approved to date or are in clinical development.

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来源期刊

New biotechnology 生物-生化研究方法

CiteScore

11.40

自引率

1.90%

发文量

审稿时长

1 months

期刊介绍： New Biotechnology is the official journal of the European Federation of Biotechnology (EFB) and is published bimonthly. It covers both the science of biotechnology and its surrounding political, business and financial milieu. The journal publishes peer-reviewed basic research papers, authoritative reviews, feature articles and opinions in all areas of biotechnology. It reflects the full diversity of current biotechnology science, particularly those advances in research and practice that open opportunities for exploitation of knowledge, commercially or otherwise, together with news, discussion and comment on broader issues of general interest and concern. The outlook is fully international. The scope of the journal includes the research, industrial and commercial aspects of biotechnology, in areas such as: Healthcare and Pharmaceuticals; Food and Agriculture; Biofuels; Genetic Engineering and Molecular Biology; Genomics and Synthetic Biology; Nanotechnology; Environment and Biodiversity; Biocatalysis; Bioremediation; Process engineering.