通过弥散和灌注 MRI 预测原发性中枢神经系统弥漫大 B 细胞淋巴瘤的 PD-L1 和 Ki-67 状态:一项初步研究。

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaofang Zhou, Feng Wang, Lan Yu, Feiman Yang, Jie Kang, Dairong Cao, Zhen Xing
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引用次数: 0

摘要

目的评估弥散和灌注核磁共振成像衍生参数能否无创预测原发性中枢神经系统弥漫大B细胞淋巴瘤(PCNS-DLBCL)的PD-L1和Ki-67状态:我们对88例PCNS-DLBCL患者的DWI、DSC-PWI和形态学磁共振成像(mMRI)进行了回顾性分析。mMRI特征的比较采用秩方检验或费舍尔精确检验。采用 Mann-Whitney U 检验比较了不同分子状态的 PCNS-DLBCL 患者的最小 ADC(ADCmin)、平均 ADC(ADCmean)、相对最小 ADC(rADCmin)、相对平均 ADC(rADCmean)和相对最大 CBV(rCBVmax)值。通过接收者操作特征曲线评估诊断效果:结果:PD-L1 高表达的 PCNS-DLBCL 的 ADCmin 值明显高于 PD-L1 低表达的 PCNS-DLBCL。高Ki-67状态的PCNS-DLBCL的ADCmean和rADCmean值明显低于低Ki-67状态的PCNS-DLBCL。ADC值对评估PD-L1和Ki-67状态的诊断效力相对较低,其曲线下面积(AUC)值低于0.7:DWI衍生的ADC值可提供PCNS-DLBCL中PD-L1和Ki-67状态的一些相关信息,但由于诊断效能较低,可能不足以预测其表达情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of PD-L1 and Ki-67 status in primary central nervous system diffuse large B-cell lymphoma by diffusion and perfusion MRI: a preliminary study.

Objective: To assess whether diffusion and perfusion MRI derived parameters could non-invasively predict PD-L1 and Ki-67 status in primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL).

Methods: We retrospectively analyzed DWI, DSC-PWI, and morphological MRI (mMRI) in 88 patients with PCNS-DLBCL. The mMRI features were compared using chi-square tests or Fisher exact test. Minimum ADC (ADCmin), mean ADC(ADCmean), relative minimum ADC (rADCmin), relative mean ADC (rADCmean), and relative maximum CBV (rCBVmax) values were compared in PCNS-DLBCL with different molecular status by using the Mann-Whitney U test. The diagnostic performances were evaluated by receiver operating characteristic curves.

Results: PCNS-DLBCL with high PD-L1 expression demonstrated a significantly higher ADCmin value than those with low PD-L1. The ADCmean and rADCmean values were significantly lower in PCNS-DLBCL with high Ki-67 status compared with those in low Ki-67 status. Other ADC, CBV parameters, and mMRI features did not show any association with these molecular statuses The diagnostic efficacy of ADC values in assessing PD-L1 and Ki-67 status was relatively low, with area under the curves (AUCs) values less than 0.7.

Conclusions: DWI-derived ADC values can provide some relevant information about PD-L1 and Ki-67 status in PCNS-DLBCL, but may not be sufficient to predict their expression due to the rather low diagnostic performance.

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来源期刊
BMC Medical Imaging
BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.60
自引率
3.70%
发文量
198
审稿时长
27 weeks
期刊介绍: BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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