Busra Candiri, Engin Ramazanoglu, Burcu Talu, Mehmet Tecellioglu
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Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used.</p><p><strong>Results: </strong> A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation.</p><p><strong>Conclusion: </strong> It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health.</p><p><strong>Trial registration: </strong> NCT06084182.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis.\",\"authors\":\"Busra Candiri, Engin Ramazanoglu, Burcu Talu, Mehmet Tecellioglu\",\"doi\":\"10.1055/s-0044-1788273\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong> Cognitive dysfunction is frequently seen in multiple sclerosis (MS). 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引用次数: 0
摘要
背景：多发性硬化症（MS）患者经常出现认知功能障碍。然而，关于其相关因素的研究结果却相互矛盾：调查有氧能力、力量、残疾、抑郁、疲劳与认知储备和功能之间的关系：方法：在认知功能评估中使用移动应用程序 "寻迹测试（TMT A-B）"、"数字跨度测试（DST）"、"视觉空间记忆测试（VSMT）"和 "快速拍击（Tap Fast）"。功能表现通过 6 分钟步行测试 (6MWT)、5 次坐到沙测试 (5STS) 和握力进行评估。此外，还使用了认知储备指数（CRI）、贝克抑郁量表、疲劳严重程度量表（FSS）和诺丁汉健康档案：多发性硬化症组和对照组仅在 6MWT、STS-5、握力、TMT、VSMT 和 Tap Fast 中存在明显差异。TMT-A 和 6MWT 与身体活动度之间存在良好的相关性。握力、能量和疼痛状况之间的相关性一般。TMT-B 和 6MWT 之间具有良好的相关性，与残疾、认知储备和疼痛之间的关系一般。DST 与 6MWT、左侧握力、疼痛和能量状态之间存在良好的相关性；右侧握力、认知储备和身体活动能力之间存在一般的相关性。VSMT 与能量之间存在良好的相关性。残疾、认知储备和疼痛之间的关系一般。Tap Fast 评分与残疾、5STS、FSS、能量和身体活动能力之间存在良好的相关性。疼痛与社会隔离之间的关系一般：结论：研究表明，多发性硬化症患者的认知能力与残疾、功能表现、认知储备、疲劳和总体健康状况有关：试验注册：NCT06084182。
The relationship between cognitive function and functional capacity, and cognitive reserve and reaction time in patients with multiple sclerosis.
Background: Cognitive dysfunction is frequently seen in multiple sclerosis (MS). However, there are conflicting findings regarding the factors it is associated with.
Objective: To investigate the relationship between aerobic capacity, strength, disability, depression, fatigue, and cognitive reserve and function.
Methods: The mobile applications Trail Making Test (TMT A-B), Digit Span Test (DST), Visuospatial Memory Test (VSMT), and Tap Fast were used in the cognitive function evaluation. Functional performance was assessed with the 6-minute walk test (6MWT), 5-Time Sit-to-Sand (5STS) test, and grip strength. Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used.
Results: A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation.
Conclusion: It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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