移植后早期血清铁蛋白水平作为小儿脐带血移植治疗急性白血病过程中严重急性移植物抗宿主病的预测生物标志物。

IF 1.1 4区 医学 Q3 SURGERY
Zhiqi Zhang, Bohan Li, Lu Liu, Ruolan Xiong, Senlin Zhang, Minyuan Liu, Zihao Xia, Shuran Wang, Jie Li, Shaoyan Hu
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引用次数: 0

摘要

背景使用脐带血进行异基因造血干细胞移植(allo-HSCT)是急性白血病(AL)患者的一种重要治疗方法。急性移植物抗宿主疾病(aGVHD)仍然是最常见的并发症。本研究调查了急性移植物抗宿主疾病的风险因素,并评估了接受脐带血移植(UCBT)的儿童急性白血病患者移植后两周内的血清铁蛋白(SF)是否是急性移植物抗宿主疾病的潜在生物标志物。材料与方法 我们对2017年至2022年间在苏州大学附属儿童医院接受UCBT的71例AL患者进行了一项回顾性队列研究。我们评估了与 aGVHD 相关的几个因素。采用Fine和Gray的比例子分布危险回归模型进行了单变量和多变量分析。采用 Kaplan-Meier 法对总生存期(OS)进行分析,并采用对数秩检验对差异进行比较。结果 71例患者中,23例(32.4%)发生了II-IV级aGVHD,其中18例(25.4%)发生了III-IV级aGVHD。II-IV级和III-IV级aGVHD患者的5年OS较差(分别为69.4±10%,P=0.01;60.6±11.6,P=0.007)。治疗强度是III-IV级aGVHD的风险因素(HR:0.34,95% CI:0.13-0.89,P=0.027)。移植后2周内SF水平>1650 ng/mL与严重aGVHD风险增加有关(HR:3.61,95% CI:1.09-11.97,P=0.036)。结论 移植后两周内的 SF 是发生严重 aGVHD 的潜在生物标志物。移植后 SF 水平越高,II-IV 级 aGVHD 和 III-IV 级 aGVHD 的发生率越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Post-Transplant Serum Ferritin Levels as Predictive Biomarkers for Severe Acute Graft-Versus-Host Disease in Pediatric Umbilical Cord Blood Transplantation for Acute Leukemia.

BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo-HSCT) using umbilical cord blood is a valuable therapy option for patients with acute leukemia (AL). Acute graft-versus-host disease (aGVHD) remains the most frequently encountered complication. This study investigated risk factors for aGVHD and assessed whether post-transplant serum ferritin (SF) within 2 weeks is a potential biomarker for aGVHD in pediatric patients with AL undergoing umbilical cord blood transplantation (UCBT). MATERIAL AND METHODS We conducted a retrospective cohort study of 71 patients with AL who underwent UCBT at the Children's Hospital of Soochow University between 2017 and 2022. We evaluated several factors related to aGVHD. Univariate and multivariate analyses were performed using the proportional subdistribution hazard regression model of Fine and Gray. Analyses of overall survival (OS) were performed using the Kaplan-Meier method, and differences were compared using log-rank tests. RESULTS Of the 71 patients, 23 (32.4%) experienced grade II-IV aGVHD, of whom 18 (25.4%) developed grade III-IV aGVHD. Patients with grade II-IV and III-IV aGVHD had worse 5-year OS (69.4±10%, p=0.01; and 60.6±11.6, P=0.007, respectively). Conditioning intensity was a risk factor for grade III-IV aGVHD (HR: 0.34, 95% CI: 0.13-0.89, P=0.027). An SF level >1650 ng/mL within 2 weeks post-transplant was associated with an increased risk of severe aGVHD (HR: 3.61, 95% CI: 1.09-11.97, P=0.036). CONCLUSIONS Post-transplant SF within 2 weeks was a potential biomarker for developing severe aGVHD. Higher levels of post-transplant SF are associated with a higher incidence of grade II-IV aGVHD and grade III-IV aGVHD.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
79
审稿时长
>12 weeks
期刊介绍: Annals of Transplantation is one of the fast-developing journals open to all scientists and fields of transplant medicine and related research. The journal is published quarterly and provides extensive coverage of the most important advances in transplantation. Using an electronic on-line submission and peer review tracking system, Annals of Transplantation is committed to rapid review and publication. The average time to first decision is around 3-4 weeks. Time to publication of accepted manuscripts continues to be shortened, with the Editorial team committed to a goal of 3 months from acceptance to publication. Expert reseachers and clinicians from around the world contribute original Articles, Review Papers, Case Reports and Special Reports in every pertinent specialty, providing a lot of arguments for discussion of exciting developments and controversies in the field.
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