7-甲基鸟嘌呤抑制结肠癌在体内的生长

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2024-04-01 DOI:10.32607/actanaturae.27422

K I Kirsanov, T I Fetisov, E E Antoshina, T G Gor'kova, L S Trukhanova, S I Shram, I Yu Nagaev, Yu A Zolotarev, L Abo Qoura, V S Pokrovsky, M G Yakubovskaya, V K Švedas, D K Nilov

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引用次数: 0

摘要

7- 甲基鸟嘌呤（7-MG）是聚（ADP-核糖）聚合酶 1 和 tRNA-鸟嘌呤转糖基化酶的天然抑制剂。最近，一些临床前试验证明了 7-MG 的安全性，并确定了小鼠胃内给药方案。本研究在 BALB/c 和 BALB/c 裸鼠移植肿瘤中研究了 7-MG 的药理活性。研究发现，在 Akatol 模型和使用人类 HCT116 细胞的异种移植模型中，7-MG 能有效穿透肿瘤组织，抑制结肠腺癌的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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7-Methylguanine Inhibits Colon Cancer Growth in Vivo.

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.