成纤维细胞自噬和增殖在皮肤抗衰老中的作用

IF 3.9

Experimental gerontology Pub Date : 2024-08-24 DOI:10.1016/j.exger.2024.112559

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引用次数: 0

摘要

皮肤作为人体最外层的保护屏障，会随着年龄增长和外界刺激而受损。真皮层成纤维细胞老化、凋亡，胶原蛋白、胶原纤维、弹力纤维、透明质酸等减少，导致皮肤失去弹性，出现皱纹。皮肤衰老是一个复杂的问题，涉及多种生物反应，治疗方法也多种多样。本综述重点探讨了自噬和细胞增殖在皮肤抗衰老中的重要性，总结了通过调节自噬和促进真皮成纤维细胞增殖来抗衰老的研究进展，并探讨了皮肤抗衰老研究的未来方向。

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Role of fibroblast autophagy and proliferation in skin anti-aging

Skin, as the outermost protective barrier of the body, becomes damaged with age and exposure to external stimuli. Dermal fibroblasts age and undergo apoptosis, which decreases collagen, collagen fibers, elastic fibers, hyaluronic acid, etc., leading skin to loss of elasticity and appearance of wrinkles. Skin aging is complex, involving several biological reactions，and various treatment methods are used to treat it. This review focuses on the importance of autophagy and cell proliferation in skin anti-aging, summarizes research progress on skin anti-aging by regulating autophagy and promoting the proliferation of dermal fibroblasts, and discusses future directions on skin anti-aging research.

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来源期刊

Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

66 days