光动力涂层能以较低的光强度杀死重症监护室中靠近病人表面的细菌。

IF 3.9 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2024-08-22 DOI:10.1016/j.jhin.2024.08.006

B. Kieninger , R. Fechter , W. Bäumler , D. Raab , A. Rath , A. Caplunik-Pratsch , S. Schmid , T. Müller , W. Schneider-Brachert , A. Eichner

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引用次数: 0

摘要

背景：医院内靠近病人的表面可能会导致医疗相关感染。这些表面是病原体的贮藏地，有利于病原体在员工和病人之间传播。对这些表面进行定期清洁和消毒只能暂时消除病原体，但不可避免地会造成再次污染。对这些表面进行抗菌涂层 (AMC) 可以额外降低病原体传播的风险。本研究旨在了解光动力涂层是否能在极低的光照强度下也有效。目的：在本校医院的两个重症监护室进行的一项实地研究中，评估标准和新型光动力 AMC 的功效：方法：测定三种涂层上的微生物负荷：标准光动力 AMC（A）、新型光动力 AMC（B）和作为对照的非活性 AMC（C）。对照涂层 C 与标准涂层 A 相同，但不含光敏剂。在 3 个月的时间里，使用 eSwab 从相同的表面收集了 699 个样本，并进行了分析（cfu/cm2）：结果：使用对照涂层（C）的所有表面的平均值显示微生物负荷为 5.5 ± 14.8 cfu/cm2。光动力 AMC 的平均值明显降低，为 1.6 ± 4.6 CFU/cm2（涂层 A；p2，微生物数量增加的相对风险分别降低了 52%（涂层 A）或 40%（涂层 B）：这两种光动力 AMC 都能大幅降低重症监护室中低光照强度下患者近表面微生物数量的永久性风险。

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Photodynamic coatings kill bacteria on near-patient surfaces in intensive care units with low light intensities

Background

Surfaces in close proximity to patients within hospitals may cause healthcare-associated infections. These surfaces are repositories for pathogens facilitating their transmission among staff and patients. Regular cleaning and disinfection of these surfaces provides only a temporary elimination of pathogens with inevitable recontamination. Antimicrobial coatings (AMCs) of such surfaces may additionally reduce the risk of pathogen transmissions.

Aim

To evaluate the efficacy of a standard and a novel photodynamic AMC, even at very low light intensities, in a field study conducted in two ICUs at our university hospital.

Methods

The microbial burden was determined on three coatings: standard photodynamic AMC (A), a novel photodynamic AMC (B), and an inactive AMC as control (C). The control coating C was identical to standard coating A, but it contained no photosensitizer. During a three-month period, 699 samples were collected from identical surfaces using eSwab and were analysed (cfu/cm²).

Findings

Mean values of all surfaces covered with control coating (C) showed a microbial burden of 5.5 ± 14.8 cfu/cm². Photodynamic AMC showed significantly lower mean value of 1.6 ± 4.6 cfu/cm² (coating A; P < 0.001) and 2.7 ± 9.6 (coating B; P < 0.001). When considering a benchmark of 2.5 cfu/cm², the relative risk for higher microbial counts was reduced by 52% (coating A) or 40% (coating B), respectively.

Conclusion

Both photodynamic AMCs offer a substantial, permanent risk reduction of microbial counts on near-patient surfaces in ICUs with low light intensities.

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.