经典迷幻药和酗酒治疗。

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Guilherme Lodetti , Rafael Mariano de Bitencourt , Eduardo Pacheco Rico
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引用次数: 0

摘要

酒精是一种有害的药物,减少酒精消费对使用者来说是一个巨大的挑战。此外,酒精依赖通常具有抗药性,目前还没有完全有效的治疗化学依赖的模式。经典的迷幻剂,如迷幻剂、西洛赛宾和死藤水,已被用于不同的临床和临床前试验,在治疗成瘾等抗药性精神病理学疾病,尤其是与酒精依赖相关的疾病方面,显示出良好的药物治疗效果。在这项工作中,我们对有关迷幻剂在酒精使用障碍治疗中的潜力的新兴研究进行了叙述性综述。迷幻药已被证明具有治疗药物成瘾(尤其是酒精成瘾)的潜力,主要是通过调节大脑的神经可塑性。鉴于5-羟色胺能迷幻剂在反复使用时不会产生身体依赖性或戒断症状,因此可被视为治疗药物使用障碍的有前途的治疗方案。不过,这种疗法也存在一定的局限性。虽然在临床研究中,许多参与者只需使用一个治疗剂量就能取得积极效果,但这些效果的持续时间存在很大的个体差异。因此,应使用不同剂量和实验方案开展进一步研究,以增强有关迷幻药的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Classic psychedelics and the treatment for alcoholism

Alcohol is a harmful drug, and reducing its consumption is a significant challenge for users. Furthermore, alcohol dependence is often treatment-resistant, and no completely effective treatment model is available for chemical dependence. Classic psychedelics, such as LSD, psilocybin, and ayahuasca have been used in different clinical and pre-clinical trials, demonstrating promising pharmacotherapeutic effects in the treatment of treatment-resistant psychopathological conditions, such as addiction, especially related to alcohol dependence. In this work, we conducted a narrative review of the emerging research regarding the potential of psychedelics for alcohol use disorder treatment. Psychedelic substances have demonstrated potential for treating drug addiction, especially AUD, mostly by modulating neuroplasticity in the brain. Given that serotonergic psychedelics do not produce physical dependence or withdrawal symptoms with repeated use, they may be considered promising treatment options for managing drug use disorders. However, certain limitations could be found. Although many participants achieve positive results with only one treatment dose in clinical studies, great inter-individual variability exists in the duration of these effects. Therefore, further studies using different doses and experimental protocols should be conducted to enhance evidence about psychedelic substances.

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来源期刊
CiteScore
12.00
自引率
1.80%
发文量
153
审稿时长
56 days
期刊介绍: Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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