Fei Tang, Hong-Yan Liu, Qi-Yuan He, Ying Liu, Li-Ping Lv, Jun Fei, Lin Fu
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引用次数: 0
摘要
背景：钴（Co）是一种广泛用于工业生产的金属。以往的研究发现，环境中的钴暴露会对多个器官产生毒性影响。然而，慢性阻塞性肺病（COPD）患者血液中 Co 浓度与肺功能的相关性并不一致：方法：招募了所有 771 名病情稳定的慢性阻塞性肺病患者。收集外周血和临床信息。结果：横断面研究表明，慢性阻塞性肺疾病（COPD）患者血液中的 Co 和血清中的 CC16 含量并不一致：横断面研究表明，血液中 Co 的水平与肺功能参数成反比，且与剂量有关。血Co每升高1 ppm，FVC下降0.598 L，FEV1下降0.465 L，FEV1/FVC%下降6.540%，FEV1%下降14.013%。此外，年龄越大、冬季入学、目前吸烟、吸烟量越大、吸入皮质类固醇等因素显著加剧了血 Co 与肺功能之间的负相关。此外，COPD 患者血清中的 CC16 含量随着血 Co 的升高而逐渐降低。此外，血清 CC16 与肺功能呈正相关，与血 Co 呈反相关。此外，CC16的降低在很大程度上分别导致11.45%和6.37%的FEV1和FEV1%在Co触发下下调：结论：血液中 Co 的升高与肺功能和血清 CC16 的降低密切相关。结论：血液中Co的升高与肺功能和血清CC16的降低密切相关。
Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein.
Background: Cobalt (Co) is a metal which is widely used in the industrial production. The previous studies found the toxic effects of environmental Co exposure on multiple organs. However, the correlation of blood Co concentration with lung function was inconsistent in patients with chronic obstructive pulmonary disease (COPD).
Methods: All 771 stable COPD patients were recruited. Peripheral blood and clinical information were collected. The levels of blood Co and serum CC16 were measured.
Results: Cross-sectional study suggested that the level of blood Co was inversely and dose-dependently related to lung function parameters. Each 1 ppm elevation of blood Co was related to 0.598 L decline in FVC, 0.465 L decline in FEV1, 6.540% decline in FEV1/FVC%, and 14.013% decline in FEV1%, respectively. Moreover, higher age, enrolled in winter, current-smoking, higher smoking amount, and inhaled corticosteroids prominently exacerbated the negative correlation between blood Co and lung function. Besides, serum CC16 content was gradually reduced with blood Co elevation in COPD patients. Besides, serum CC16 was positively correlated with lung function, and inversely related to blood Co. Additionally, decreased CC16 substantially mediated 11.45% and 6.37% Co-triggered downregulations in FEV1 and FEV1%, respectively.
Conclusion: Blood Co elevation is closely related to the reductions of pulmonary function and serum CC16. CC16 exerts a significantly mediating role of Co-related to pulmonary function decrease among COPD patients.
期刊介绍：
Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases.
As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion.
Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.
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