中国年轻人肥胖相关癌症发病率上升:基于人口的分析(2007-2021 年)》。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Med Pub Date : 2024-11-08 Epub Date: 2024-08-23 DOI:10.1016/j.medj.2024.07.012
Chang Liu, Ying-Chao Yuan, Mo-Ning Guo, Zhong Xin, Guan-Jie Chen, Nan Ding, Jian-Peng Zheng, Bai Zang, Jin-Kui Yang
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引用次数: 0

摘要

背景:发展中国家面临着 "肥胖流行病",尤其是儿童和年轻人。虽然肥胖是 12 种癌症的已知风险因素,主要影响老年人群,但其对年轻一代的影响却未得到充分研究:本研究分析了中国 1 414 万人口癌症登记数据(2007-2021 年)。我们比较了肥胖和非肥胖相关癌症的发病率,并应用年龄-时期-队列模型估算了其影响:在 651 342 例癌症病例中,48.47% 与肥胖有关。12 种与肥胖有关的癌症的年龄标准化发病率每年增加 3.6%(p 结论:肥胖导致的癌症发病率增加,与肥胖有关的癌症发病率每年增加 3.6%,与肥胖有关的癌症发病率每年增加 3.6%:肥胖相关癌症在青壮年中的发病率不断上升,是一个重大的公共卫生问题。日益加重的癌症负担突出表明,有必要采取有针对性的干预措施来应对肥胖症的流行:本研究得到国家自然科学基金(81930019,82341076)的资助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rising incidence of obesity-related cancers among younger adults in China: A population-based analysis (2007-2021).

Background: Developing countries face an "obesity epidemic," particularly affecting children and younger adults. While obesity is a known risk factor for 12 types of cancer, primarily affecting older populations, its impact on younger generations is understudied.

Methods: This study analyzed data from a population-based cancer registry covering 14.14 million individuals in China (2007-2021). We compared the incidence of obesity- and non-obesity-related cancers and applied an age-period-cohort model to estimate their impacts.

Findings: Among 651,342 cancer cases, 48.47% were obesity related. The age-standardized incidence rates (ASRs) of the 12 obesity-related cancers increased annually by 3.6% (p < 0.001), while ASRs for non-obesity-related cancers remained stable. Obesity-related cancers surged among younger adults, with rates rising across successive generations. The annual percentage of change decreased with age, from 15.28% for ages 25-29 years to 1.55% for ages 60-64 years. The incidence rate ratio for obesity-related cancer was higher in younger generations compared to those born in 1962-1966. We predict that the ASR for obesity-related cancers will nearly double in the next decade.

Conclusions: The rising incidence of obesity-related cancers among young adults poses a significant public health concern. The increasing cancer burden underscores the need for targeted interventions to address the obesity epidemic.

Funding: This work was supported by the National Natural Science Foundation of China (81930019, 82341076) to J.-K.Y.

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来源期刊
Med
Med MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
17.70
自引率
0.60%
发文量
102
期刊介绍: Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.
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