二尖瓣发育和脱垂的最新基因图谱。

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-08-13 DOI:10.1016/j.prp.2024.155535

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引用次数: 0

摘要

本综述旨在全面概述截至 2024 年 2 月在 PubMed 数据库上发表的有关二尖瓣疾病发展的文献，并详细介绍二尖瓣脱垂从胚胎学到遗传学的概况。在涉及二尖瓣胚胎学的 3291 篇文献中，有 215 篇涉及二尖瓣遗传学，其中 83 篇被选中进行进一步分析。在回顾这些数据后，我们认为以基因为基础的疗法非常重要，这种疗法应该很快就能问世，以预防或治疗非侵入性的瓣膜退化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Update on the genetic profile of mitral valve development and prolapse

The purpose of this review is to present a comprehensive overview of the literature published up to February 2024 on the PubMed database regarding the development of mitral valve disease, with detailed reference to mitral valve prolapse, from embryology to a genetic profile. Out of the 3291 publications that deal with mitral valve embryology, 215 refer to mitral valve genetics and 83 were selected for further analysis. After reviewing these data, we advocate for the importance of a gene-based therapy that should be available soon, to prevent or treat non-invasively the valvular degeneration.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.