洞察γ和δ生育三烯酚在结直肠癌中的抗癌机制。

IF 5.9 2区 医学 Q1 NUTRITION & DIETETICS
Ali Qusay Khalid, Tabarek Najeeb Zaidan, Saatheeyavaane Bhuvanendran, Kasthuri B Magalingam, Shaza M Mohamedahmed, Premdass Ramdas, Ammu K Radhakrishnan
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引用次数: 0

摘要

大肠癌(CRC)是全世界日益关注的问题。人们一直在协力寻找可用于预防或治疗这种疾病的天然生物活性化合物。生育三烯酚(T3s)是一种天然存在的维生素 E,具有抗癌、抗氧化、神经保护和抗炎等多种治疗作用。文献证据表明,两种T3类似物,即γ(γ)-T3和δ(δ)-T3,可通过几种与癌症相关的信号通路调节癌症。本综述旨在整理和分析γT3和δT3在CRC细胞中表现出的多种抗癌机制的现有文献,以展示T3s的抗癌潜力。我们在 Medline 上检索了过去二十年中发表的有关 γT3 和 δT3 在 CRC 中的抗癌作用的研究文章。共找到 38 篇报道γT3 和δT3 在 CRC 中抗癌作用的文章(26 篇细胞研究、9 篇动物研究、2 篇随机临床试验和 1 篇范围综述)。这些文章的研究结果表明,γT3 和 δT3 可抑制 CRC 细胞的增殖,诱导细胞周期停滞和凋亡,抑制转移,并在与成熟的抗癌药物联合使用时产生协同抗癌效应。有初步证据表明,T3s 会影响端粒酶功能并支持抗癌免疫反应。γT3和δT3具有作为抗癌剂开发的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights into the Anticancer Mechanisms Modulated by Gamma and Delta Tocotrienols in Colorectal Cancers.

Colorectal cancer (CRC) is a growing concern all over the world. There has been a concerted effort to identify natural bioactive compounds that can be used to prevent or overcome this condition. Tocotrienols (T3s) are a naturally occurring form of vitamin E known for various therapeutic effects, such as anticancer, antioxidant, neuroprotective, and anti-inflammatory activities. The literature evidence suggests that two T3 analogues, ie, gamma (γ)- and delta (δ)-T3, can modulate cancers via several cancer-related signaling pathways. The aim of this review was to compile and analyze the existing literature on the diverse anticancer mechanisms of γT3 and δT3 exhibited in CRC cells, to showcase the anticancer potential of T3s. Medline was searched for research articles on anticancer effects of γT3 and δT3 in CRC published in the past 2 decades. A total of 38 articles (26 cell-based, 9 animal studies, 2 randomized clinical trials, and 1 scoping review) that report anticancer effects of γT3 and δT3 in CRC were identified. The findings reported in those articles indicate that γT3 and δT3 inhibit the proliferation of CRC cells, induce cell cycle arrest and apoptosis, suppress metastasis, and produce synergistic anticancer effects when combined with well-established anticancer agents. There is preliminary evidence that shows that T3s affect telomerase functions and support anticancer immune responses. γT3 and δT3 have the potential for development as anticancer agents.

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来源期刊
Nutrition reviews
Nutrition reviews 医学-营养学
CiteScore
12.20
自引率
1.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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