卡利霉素治疗急性髓性白血病并发危及生命的混合性肛周感染患者：病例报告与文献综述

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.2147/IDR.S475982

Xiawan Yang, Yingying Shen, Tonglin Hu, Hangchao Li, Yun Zhang, Yiping Shen, Dijiong Wu

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引用次数: 0

摘要

背景：急性髓性白血病（AML）患者肛周感染的发病率和死亡率都很高。有时缺乏有效的抗感染治疗方案：一名 58 岁男性患者被诊断为急性髓性白血病，入院时出现继发性肛周感染和脓毒性休克。虽然多种病原体培养和抗生素敏感试验显示存在敏感菌株，但相应的抗生素均无效。在不得已的情况下，患者使用了卡瑞霉素，最终控制了感染，病情得到缓解：结论：卡瑞霉素是常规抗生素治疗失败后的一种辅助治疗选择。结论：卡瑞霉素是常规抗生素治疗失败后的一种辅助治疗选择，它的作用机制超出了其抗生素特性，值得进一步研究。

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Carrimycin in a Patient with Acute Myeloid Leukemia Complicated with Life-Threatening Mixed Perianal Infection: A Case Report and Literature Review.

Background: Perianal infection has a high incidence and mortality rate in patients with acute myeloid leukemia (AML). Sometimes there is a lack of effective anti-infective treatment regimens.

Case presentation: A 58-year-old male diagnosed with AML presented with secondary perianal infection and septic shock upon admission. Although multiple pathogen cultivation and antibiotic sensitivity tests indicated the presence of sensitive strains, the corresponding antibiotics were ineffective. As a last resort, carrimycin was introduced, ultimately controlling the infection and leading to disease remission.

Conclusion: Carrimycin is a complementary treatment option when conventional antibiotic therapy fails. It operates through multiple mechanisms beyond its antibiotic properties and warrants further investigation.

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.