慢性肾病患者吸入妥布霉素的治疗药物监测。

IF 1.6 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Rebeca Añez-Castaño, Carles Iniesta-Navalón, Miguel Almanchel-Rivadeneyra, Eva García-Villalba, Eva Oliver-Galera, Lorena Rentero-Redondo
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引用次数: 0

摘要

本病例报告调查了一名慢性肾病患者吸入妥布霉素后血清浓度升高的情况。患者是一名 80 多岁的男性,患有复杂的并发症,因铜绿假单胞菌引起的慢性呼吸道感染而接受了妥布霉素吸入治疗,尽管采取了战略性的局部治疗方法,但仍观察到出乎意料的高血浆妥布霉素浓度。在药代动力学-药效学模型指导下进行剂量调整后,最终确定每 24 小时吸入 300 毫克妥布霉素。本病例报告强调了对接受吸入妥布霉素治疗的肾功能损害患者进行血浆妥布霉素水平严格监测的必要性,并提倡加强药代动力学模型以提高治疗的安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic drug monitoring of inhaled tobramycin in a patient with chronic kidney disease.

This case report investigates elevated serum concentrations of inhaled tobramycin in a patient with chronic kidney disease. The patient, a man in his early 80s with complex comorbidities, underwent tobramycin inhalation therapy for chronic respiratory infections caused by Pseudomonas aeruginosa Despite the strategic localised treatment approach, unexpectedly high plasma tobramycin concentrations were observed. After a dosage adjustment guided by a pharmacokinetic-pharmacodynamic model, a final inhalation dose of 300 mg of tobramycin was determined at a 24-hour interval. This case report underscores the need for rigorous monitoring of plasma tobramycin levels in patients with renal impairment undergoing inhaled tobramycin therapy, advocating for enhanced pharmacokinetic models to improve the safety and efficacy of the treatment.

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来源期刊
CiteScore
3.40
自引率
5.90%
发文量
104
审稿时长
6-12 weeks
期刊介绍: European Journal of Hospital Pharmacy (EJHP) offers a high quality, peer-reviewed platform for the publication of practical and innovative research which aims to strengthen the profile and professional status of hospital pharmacists. EJHP is committed to being the leading journal on all aspects of hospital pharmacy, thereby advancing the science, practice and profession of hospital pharmacy. The journal aims to become a major source for education and inspiration to improve practice and the standard of patient care in hospitals and related institutions worldwide. EJHP is the only official journal of the European Association of Hospital Pharmacists.
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