根据 SCORE2-糖尿病算法,骨蛋白与心血管风险有关。

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Sheila González-Salvatierra, Antonia García-Martín, Beatriz García-Fontana, Luis Martínez-Heredia, Cristina García-Fontana, Manuel Muñoz-Torres
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引用次数: 0

摘要

背景:典型的骨蛋白(如硬骨蛋白和骨膜蛋白)与心血管疾病(CVD)有关。与此同时,还开发出了几种风险评分来预测普通人群中的心血管疾病。因此,我们的目的是评估这些与心血管疾病相关的骨蛋白与主要血管风险量表之间的关联:弗雷明汉风险评分(FRS)、REGICOR 和 SCORE2-糖尿病。我们特别关注 SCORE2-Diabetes 算法,该算法可预测 10 年心血管疾病风险,是研究人群的特有算法:这是一项横断面研究,包括 104 名 2 型糖尿病患者(62 ± 6 岁,60% 为男性)。研究收集了临床数据、生化测量结果、血清生物活性硬蛋白和包膜蛋白水平,并计算了不同的风险量表。分析了生物活性硬骨素或骨膜增生蛋白与风险量表之间的关联:结果:生物活性硬骨蛋白(p 131 pmol/L)与循环水平之间呈正相关,灵敏度为 51.6%,特异度为 78.6%。同样,血清包膜生长因子水平> 1144 pmol/L的敏感性为64.5%,特异性为76.2%:结论:在 SCORE2-Diabetes 算法中,硬骨蛋白和骨膜增生蛋白与血管风险相关,为确定 2 型糖尿病人群心血管风险的新型生物标志物开辟了一条新的研究路线。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bone proteins are associated with cardiovascular risk according to the SCORE2-Diabetes algorithm.

Background: Typical bone proteins, such as sclerostin and periostin, have been associated with cardiovascular disease (CVD). Simultaneously, several risk scores have been developed to predict CVD in the general population. Therefore, we aimed to evaluate the association of these bone proteins related to CVD, with the main vascular risk scales: Framingham Risk Score (FRS), REGICOR and SCORE2-Diabetes, in patients with type 2 diabetes. We focus in particular on the SCORE2-Diabetes algorithm, which predicts 10-year CVD risk and is specific to the study population.

Methods: This was a cross-sectional study including 104 patients with type 2 diabetes (62 ± 6 years, 60% males). Clinical data, biochemical measurements, and serum bioactive sclerostin and periostin levels were collected, and different risk scales were calculated. The association between bioactive sclerostin or periostin with the risk scales was analyzed.

Results: A positive correlation was observed between circulating levels of bioactive sclerostin (p < 0.001) and periostin (p < 0.001) with SCORE2-Diabetes values. However, no correlation was found with FRS or REGICOR scales. Both serum bioactive sclerostin and periostin levels were significantly elevated in patients at high-very high risk of CVD (score ≥ 10%) than in the low-moderate risk group (score < 10%) (p < 0.001 for both). Moreover, analyzing these proteins to identify patients with type 2 diabetes at high-very high vascular risk using ROC curves, we observed significant AUC values for bioactive sclerostin (AUC = 0.696; p = 0.001), periostin (AUC = 0.749; p < 0.001), and the model combining both (AUC = 0.795; p < 0.001). For diagnosing high-very high vascular risk, serum bioactive sclerostin levels > 131 pmol/L showed 51.6% sensitivity and 78.6% specificity. Similarly, serum periostin levels > 1144 pmol/L had 64.5% sensitivity and 76.2% specificity.

Conclusions: Sclerostin and periostin are associated with vascular risk in the SCORE2-Diabetes algorithm, opening a new line of investigation to identify novel biomarkers of cardiovascular risk in the type 2 diabetes population.

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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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