胞嘧啶甲基化标志着线粒体 RNA 的降解。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-10-01 DOI:10.1016/j.tibs.2024.08.001

Emeline Recazens , Alexis A. Jourdain

引用次数: 0

摘要

线粒体双链 RNA（dsRNA）可在线粒体中自发形成，阻碍线粒体基因表达并引发免疫反应。Kim、Tan 等人最近的一项研究发现了一种保障机制，其中 NOP2/Sun RNA 甲基转移酶 4（NSUN4）介导的 RNA 甲基化（m5C）可招募 RNA 降解机制来防止 dsRNA 的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cytosine methylation flags mitochondrial RNA for degradation

Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A recent study by Kim, Tan, et al. identified a safeguard mechanism in which NOP2/Sun RNA methyltransferase 4 (NSUN4)-mediated RNA methylation (m⁵C) recruits the RNA degradation machinery to prevent dsRNA formation.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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