STRAP 通过靶向 TBK1 上调针对 PRV 的抗病毒先天免疫。

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2024-08-24 DOI:10.1186/s12985-024-02474-z

Wenfeng He, Hongtao Chang, Chen Li, Chenlong Wang, Longxi Li, Guoqing Yang, Jing Chen, Huimin Liu

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引用次数: 0

摘要

丝氨酸/苏氨酸激酶受体相关蛋白（STRAP）是一种支架蛋白，参与多种细胞活动，但其在抗病毒先天免疫中的重要性尚不清楚。我们发现 STRAP 可作为干扰素（IFN）诱导的正调控因子，在伪狂犬病毒感染期间促进 IFN 信号传导。从机制上讲，STRAP 与 TBK1 相互作用，激活 I 型 IFN 信号。CT 和 WD40 7 - 6 结构域都有助于发挥 STRAP 的功能。此外，TBK1 会与 PRV-UL50 竞争与 STRAP 的结合，而 STRAP 会阻碍 PRV-UL50 介导的 TBK1 降解，从而增加 STRAP 与 TBK1 之间的相互作用。总之，这些发现揭示了 STRAP 在 PRV 感染期间的先天性抗病毒免疫反应中的作用，而这一作用以前从未被认识到。STRAP 可能是病毒性传染病的潜在治疗靶点。

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STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.

Serine/threonine kinase receptor-associated protein (STRAP) serves as a scaffold protein and is engaged in a variety of cellular activities, although its importance in antiviral innate immunity is unknown. We discovered that STRAP works as an interferon (IFN)-inducible positive regulator, facilitating type I IFN signaling during pseudorabies virus infection. Mechanistically, STRAP interacts with TBK1 to activate type I IFN signaling. Both the CT and WD40 7 - 6 domains contribute to the function of STRAP. Furthermore, TBK1 competes with PRV-UL50 for binding to STRAP, and STRAP impedes the degradation of TBK1 mediated by PRV-UL50, thereby increasing the interaction between STRAP and TBK1. Overall, these findings reveal a previously unrecognized role for STRAP in innate antiviral immune responses during PRV infection. STRAP could be a potential therapeutic target for viral infectious diseases.

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.