{"title":"乳腺癌化疗和放疗后出现 ZMYND11::MBTD1 融合基因的急性髓性白血病：病例报告","authors":"Hidetsugu Kawai , Sawako Shiraiwa , Daisuke Ogiya , Masako Toyosaki , Shinichiro Machida , Rikio Suzuki , Makoto Onizuka , Yoshiaki Ogawa , Hiroshi Kawada","doi":"10.1016/j.lrr.2024.100478","DOIUrl":null,"url":null,"abstract":"<div><p>The t(10;17)(p15;q21) translocation is a very rare recurrent cytogenetic aberration, and produced <em>ZMYND11::MBTD1</em> fusion gene. To date, nine cases of acute leukemia with the t(10;17)(p15;q21) translocation have been reported, but the case of AML with <em>ZMYND11::MBTD1</em> after chemotherapy and radiotherapy have not been reported. Epirubicin-based chemotherapy or radiotherapy for breast cancer increases the risk of developing secondary leukemia. We report a case of AML with the <em>ZMYND11::MBTD1</em> fusion gene that developed after epirubicin-based chemotherapy and radiotherapy for breast cancer. previous chemotherapy and radiotherapy may be associated with poor prognosis of AML with <em>ZMYND11/MBTD1</em>.</p></div>","PeriodicalId":38435,"journal":{"name":"Leukemia Research Reports","volume":"22 ","pages":"Article 100478"},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213048924000682/pdfft?md5=ce7223922598a44c6fcf072460505d41&pid=1-s2.0-S2213048924000682-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Acute myeloid leukemia with a ZMYND11::MBTD1 fusion gene following chemotherapy and radiotherapy for breast cancer: A case report\",\"authors\":\"Hidetsugu Kawai , Sawako Shiraiwa , Daisuke Ogiya , Masako Toyosaki , Shinichiro Machida , Rikio Suzuki , Makoto Onizuka , Yoshiaki Ogawa , Hiroshi Kawada\",\"doi\":\"10.1016/j.lrr.2024.100478\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The t(10;17)(p15;q21) translocation is a very rare recurrent cytogenetic aberration, and produced <em>ZMYND11::MBTD1</em> fusion gene. To date, nine cases of acute leukemia with the t(10;17)(p15;q21) translocation have been reported, but the case of AML with <em>ZMYND11::MBTD1</em> after chemotherapy and radiotherapy have not been reported. Epirubicin-based chemotherapy or radiotherapy for breast cancer increases the risk of developing secondary leukemia. We report a case of AML with the <em>ZMYND11::MBTD1</em> fusion gene that developed after epirubicin-based chemotherapy and radiotherapy for breast cancer. previous chemotherapy and radiotherapy may be associated with poor prognosis of AML with <em>ZMYND11/MBTD1</em>.</p></div>\",\"PeriodicalId\":38435,\"journal\":{\"name\":\"Leukemia Research Reports\",\"volume\":\"22 \",\"pages\":\"Article 100478\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000682/pdfft?md5=ce7223922598a44c6fcf072460505d41&pid=1-s2.0-S2213048924000682-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Leukemia Research Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213048924000682\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia Research Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213048924000682","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Acute myeloid leukemia with a ZMYND11::MBTD1 fusion gene following chemotherapy and radiotherapy for breast cancer: A case report
The t(10;17)(p15;q21) translocation is a very rare recurrent cytogenetic aberration, and produced ZMYND11::MBTD1 fusion gene. To date, nine cases of acute leukemia with the t(10;17)(p15;q21) translocation have been reported, but the case of AML with ZMYND11::MBTD1 after chemotherapy and radiotherapy have not been reported. Epirubicin-based chemotherapy or radiotherapy for breast cancer increases the risk of developing secondary leukemia. We report a case of AML with the ZMYND11::MBTD1 fusion gene that developed after epirubicin-based chemotherapy and radiotherapy for breast cancer. previous chemotherapy and radiotherapy may be associated with poor prognosis of AML with ZMYND11/MBTD1.
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