{"title":"挖掘氧化锌纳米颗粒在增强局部给药方面的潜力","authors":"","doi":"10.1016/j.nanoso.2024.101302","DOIUrl":null,"url":null,"abstract":"<div><p>This review explores the pivotal role of zinc oxide nanoparticles in advancing modern topical drug delivery. Delving into topical drug delivery systems, it addresses the significance, challenges, and current trends. The section on zinc oxide nanoparticles provides a comprehensive overview, encompassing their properties, synthesis methods, and characterization techniques, highlighting their unique advantages in drug delivery. The focal point of the review is the multifaceted application of zinc oxide nanoparticles in topical drug delivery, showcasing their effectiveness in anti-inflammatory treatments, psoriasis management, combating skin cancer, antibacterial interventions, and promoting wound healing. Intradermal application of zinc oxide nanoparticles demonstrated notable efficacy in diminishing skin infection, lowering bacterial burden, and alleviating inflammation, concurrently fostering enhancement in the structural integrity of the infected skin. To recapitulate the remarkable properties of zinc oxide nanoparticles, offer an excellent alternative for revolutionizing topical drug delivery. Their enhanced permeation, stability, and biocompatibility offer tremendous potential for improving therapeutic outcomes.</p></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":null,"pages":null},"PeriodicalIF":5.4500,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unlocking potential of zinc oxide nanoparticles in enhancing topical drug delivery\",\"authors\":\"\",\"doi\":\"10.1016/j.nanoso.2024.101302\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This review explores the pivotal role of zinc oxide nanoparticles in advancing modern topical drug delivery. Delving into topical drug delivery systems, it addresses the significance, challenges, and current trends. The section on zinc oxide nanoparticles provides a comprehensive overview, encompassing their properties, synthesis methods, and characterization techniques, highlighting their unique advantages in drug delivery. The focal point of the review is the multifaceted application of zinc oxide nanoparticles in topical drug delivery, showcasing their effectiveness in anti-inflammatory treatments, psoriasis management, combating skin cancer, antibacterial interventions, and promoting wound healing. Intradermal application of zinc oxide nanoparticles demonstrated notable efficacy in diminishing skin infection, lowering bacterial burden, and alleviating inflammation, concurrently fostering enhancement in the structural integrity of the infected skin. To recapitulate the remarkable properties of zinc oxide nanoparticles, offer an excellent alternative for revolutionizing topical drug delivery. Their enhanced permeation, stability, and biocompatibility offer tremendous potential for improving therapeutic outcomes.</p></div>\",\"PeriodicalId\":397,\"journal\":{\"name\":\"Nano-Structures & Nano-Objects\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4500,\"publicationDate\":\"2024-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Structures & Nano-Objects\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352507X24002130\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X24002130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
Unlocking potential of zinc oxide nanoparticles in enhancing topical drug delivery
This review explores the pivotal role of zinc oxide nanoparticles in advancing modern topical drug delivery. Delving into topical drug delivery systems, it addresses the significance, challenges, and current trends. The section on zinc oxide nanoparticles provides a comprehensive overview, encompassing their properties, synthesis methods, and characterization techniques, highlighting their unique advantages in drug delivery. The focal point of the review is the multifaceted application of zinc oxide nanoparticles in topical drug delivery, showcasing their effectiveness in anti-inflammatory treatments, psoriasis management, combating skin cancer, antibacterial interventions, and promoting wound healing. Intradermal application of zinc oxide nanoparticles demonstrated notable efficacy in diminishing skin infection, lowering bacterial burden, and alleviating inflammation, concurrently fostering enhancement in the structural integrity of the infected skin. To recapitulate the remarkable properties of zinc oxide nanoparticles, offer an excellent alternative for revolutionizing topical drug delivery. Their enhanced permeation, stability, and biocompatibility offer tremendous potential for improving therapeutic outcomes.
期刊介绍：
Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .
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