Samantha Hayward, Patrick S Keogh, Anthony W Miles, Sabina Gheduzzi
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引用次数: 0
摘要
椎间盘(IVD)的环状纤维(AF)和髓核(NP)共同作用以分散脊柱负荷。在这项研究中,我们分离了髓核对椎间盘整体响应的贡献,并研究了椎间盘极端结构变化对其机械行为的影响。线性刚度、总体负荷范围、滞后面积和总能量被用来评估这些变化对脊柱和周围结构的影响。在以下三种条件下,对六个猪腰椎间盘标本进行了 6 DOFs、400 N 压缩轴向预载荷和低应变率测试:完整(IN)、全髓核切除(NN)和向髓核空隙注入骨水泥(SN)。选择后两种条件(NN 和 SN)是为了模拟 NP 的极端变化对椎间盘行为的影响。与完整样本相比,主要在轴向压缩-拉伸、内外侧弯曲和屈曲-拉伸方面发生了显著变化。与完好(IN)状态相比,NN和SN情况下的线性刚度、总体载荷范围以及内外侧弯曲和屈伸的总能量都有显著增加。SN 还显示轴向压缩-伸展的总能量显著增加,除屈曲-伸展外,弹性对所有轴向总能量的贡献显著减少。总能量的这些变化表明,在椎间盘结构发生变化后,周围的脊柱结构将承受额外的负荷以产生相同的体内运动。
The effect of structural changes on the low strain rate behaviour of the intervertebral disc.
The annuus fibrosus (AF) and nucleus pulposus (NP) of the intervertebral disc (IVD) work in conjunction to dissipate spinal loads. In this study we have isolated the contribution of the NP to the overall response of the disc and investigated the effect of extreme structural changes to the disc on the mechanical behaviour. Linear stiffness, overall load range, hysteresis area and total energy were used to evaluate the impact of these changes on the spine and surrounding structures. Six porcine lumbar isolated disc specimens were tested in 6 DOFs with a 400 N compressive axial preload at low strain rates in three conditions: intact (IN), after total nucleotomy (NN) and after the injection of bone cement into the nuclear void (SN). The latter two conditions, NN and SN, were chosen to emulate the effect of extreme changes to the NP on disc behaviour. When comparing with intact specimens, significant changes were noted primarily in axial compression-extension, mediolateral bending and flexion-extension. NN and SN cases demonstrated significant increases in linear stiffness, overall load range and total energy for mediolateral bending and flexion-extension compared to the intact (IN) state. SN also demonstrated a significant increase in total energy for axial compression-extension, and significant decreases in the elastic contribution to total energy in all axes except flexion-extension. These changes to total energy indicate that surrounding spinal structures would incur additional loading to produce the same motion in vivo after structural changes to the disc.
期刊介绍:
The Journal of Engineering in Medicine is an interdisciplinary journal encompassing all aspects of engineering in medicine. The Journal is a vital tool for maintaining an understanding of the newest techniques and research in medical engineering.