组蛋白乙酰转移酶 1 在预后不良的高级别脑膜癌和胶质脑癌中过度表达:免疫组织化学和表观组织化学研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-08-24 DOI:10.1369/00221554241272341
Sandra Bargiela-Cuevas, María Marin, María Gabaldon-Ojeda, José I Klett-Mingo, Paula Granado, Silvia Sacristan, Alfonso Esteban-Lasso, José G Casas, María E Martin, Victor M M González, Mar Royuela, Ignacio García-Tuñon, Miguel Angel Ortega Núñez, María Del Val Toledo Lobo
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引用次数: 0

摘要

中枢神经系统原发性恶性肿瘤占成人癌症总数的 2%,占 15 岁以下儿童癌症总数的近 15%。脑无性细胞瘤和胶质母细胞瘤的预后仍然极差,预期生存率极低,因此新的分子标记和治疗靶点至关重要。表观遗传变化是开发新的诊断和治疗策略的一个广泛领域。组蛋白乙酰转移酶-1(HAT1)已成为不同恶性肿瘤的潜在预后标志物和治疗靶点。资料库分析表明,HAT1 mRNA 在胶质瘤中过度表达,并且在胶质母细胞瘤中有替代剪接的描述。我们使用免疫组化和组织化学方法分析了 HAT1 在脑膜瘤、少突胶质瘤和星形胶质细胞癌中的表达。我们发现,HAT1 的过表达与侵袭性最强的肿瘤类型、预后较差以及脑膜瘤早期复发的概率较高有关。HAT1的胞浆定位与肿瘤的进展和预后相关。肽聚体是一种合成的寡核苷酸,能够结合和抑制多种靶标,被认为是很有前途的诊断和治疗工具。与所使用的抗体相比,使用aptamer apHAT610的免疫组化结果更优越,这充分证明了aptamer作为组织病理学诊断工具的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histone Acetyl Transferase 1 Is Overexpressed in Poor Prognosis, High-grade Meningeal and Glial Brain Cancers: Immunohistochemical and Aptahistochemical Study.

Primary malignancies of the central nervous system account for 2% of all cancers in adults and almost 15% in children under 15 years of age. The prognosis of brain anaplastic cancers and glioblastomas remains extremely poor, with devastating survival expectative, and new molecular markers and therapeutic targets are essential. Epigenetic changes constitute an extensive field for the development of new diagnostic and therapeutic strategies. Histone acetyl transferase-1 (HAT1) has merged as a potential prognostic marker and therapy target for different malignancies. Data repository analysis showed HAT1 mRNA overexpression in gliomas and has been described its alternative splicing in glioblastomas. Using immunohistochemical and aptahistochemical methods, we analyzed the expression of HAT1 in meningiomas, oligodendrogliomas, and astroglial cancers. We observed that HAT1 overexpression is associated with the most aggressive tumor types and the worse prognosis, as well as with a higher probability of early relapse in meningiomas. Its cytosolic localization correlates with tumor progression and prognosis. Aptamers, synthetic oligonucleotides capable to bind and inhibit a wide variety of targets, are considered as promising diagnostic and therapeutic tools. Aptahistochemistry using the aptamer apHAT610 offered superior results in comparison with the antibody used, as a good example of the potential of aptamers as diagnostic tools for histopathology.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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