更年期、心外膜脂肪和射血分数保留型心力衰竭。

IF 3.2 2区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology Pub Date : 2024-08-22 DOI:10.1016/j.ijcard.2024.132478

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引用次数: 0

摘要

在保留射血功能的心力衰竭人群中，绝经后女性所占比例过高。在绝经过渡期，内脏和心外膜脂肪组织的扩张会导致局部和低度全身性炎症，进而导致左心室同心重塑、舒张功能障碍以及射血分数保留的发生和发展。与内脏脂肪组织成像不同，心外膜脂肪组织可以通过低辐射冠状动脉钙化评分计算机断层扫描检查成像，成本低廉。绝经过渡期为评估心外膜脂肪组织扩张对保留射血分数心衰发病机制的影响提供了一个独特的时间框架。

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Menopause, epicardial adiposity and preserved ejection fraction heart failure

Postmenopausal women are overrepresented in the preserved ejection heart failure population. Expansion of visceral and epicardial adipose tissue during the menopause transition leads to local and low-grade systemic inflammation that in turn contributes to left ventricular concentric remodeling, diastolic dysfunction and the development and progression of preserved ejection fraction. In contrast to visceral adipose tissue imaging, epicardial adipose tissue can be inexpensively imaged on low radiation coronary calcium score computerized tomography examination. The menopause transition provides a unique time frame to evaluate the contribution of epicardial adipose tissue expansion to the pathogenesis of preserved ejection heart failure.

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来源期刊

International journal of cardiology 医学-心血管系统

CiteScore

6.80

自引率

5.70%

发文量

758

审稿时长

44 days

期刊介绍： The International Journal of Cardiology is devoted to cardiology in the broadest sense. Both basic research and clinical papers can be submitted. The journal serves the interest of both practicing clinicians and researchers. In addition to original papers, we are launching a range of new manuscript types, including Consensus and Position Papers, Systematic Reviews, Meta-analyses, and Short communications. Case reports are no longer acceptable. Controversial techniques, issues on health policy and social medicine are discussed and serve as useful tools for encouraging debate.