人类生物途径的化学覆盖范围。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-08-22 DOI:10.1016/j.drudis.2024.104144

Haejin Angela Kwak , Lihua Liu , Claudia Tredup , Sandra Röhm , Panagiotis Prinos , Jark Böttcher , Matthieu Schapira

{"title":"人类生物途径的化学覆盖范围。","authors":"Haejin Angela Kwak , Lihua Liu , Claudia Tredup , Sandra Röhm , Panagiotis Prinos , Jark Böttcher , Matthieu Schapira","doi":"10.1016/j.drudis.2024.104144","DOIUrl":null,"url":null,"abstract":"<div><p>Chemical probes and chemogenomic compounds are valuable tools to link gene to phenotype, explore human biology, and uncover novel targets for precision medicine. The mission of the Target 2035 initiative is to discover chemical tools for all human proteins by the year 2035. Here, we draw a landscape of the current chemical coverage of human biological pathways. Although available chemical tools target only 3% of the human proteome, they already cover 53% of human biological pathways and represent a versatile toolkit to dissect a vast portion of human biology. Pathways targeted by existing drugs may be enriched in unknown but valid drug targets and could be prioritized in future Target 2035 efforts.</p></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"29 10","pages":"Article 104144"},"PeriodicalIF":6.5000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1359644624002691/pdfft?md5=fd391cdfa8c932ff2a0d499beadcdad0&pid=1-s2.0-S1359644624002691-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Chemical coverage of human biological pathways\",\"authors\":\"Haejin Angela Kwak , Lihua Liu , Claudia Tredup , Sandra Röhm , Panagiotis Prinos , Jark Böttcher , Matthieu Schapira\",\"doi\":\"10.1016/j.drudis.2024.104144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chemical probes and chemogenomic compounds are valuable tools to link gene to phenotype, explore human biology, and uncover novel targets for precision medicine. The mission of the Target 2035 initiative is to discover chemical tools for all human proteins by the year 2035. Here, we draw a landscape of the current chemical coverage of human biological pathways. Although available chemical tools target only 3% of the human proteome, they already cover 53% of human biological pathways and represent a versatile toolkit to dissect a vast portion of human biology. Pathways targeted by existing drugs may be enriched in unknown but valid drug targets and could be prioritized in future Target 2035 efforts.</p></div>\",\"PeriodicalId\":301,\"journal\":{\"name\":\"Drug Discovery Today\",\"volume\":\"29 10\",\"pages\":\"Article 104144\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2024-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1359644624002691/pdfft?md5=fd391cdfa8c932ff2a0d499beadcdad0&pid=1-s2.0-S1359644624002691-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1359644624002691\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359644624002691","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

化学探针和化学基因组化合物是将基因与表型联系起来、探索人类生物学和发现精准医学新靶点的宝贵工具。目标 2035 计划的使命是到 2035 年发现所有人类蛋白质的化学工具。在这里，我们描绘了目前人类生物通路的化学覆盖范围。虽然现有的化学工具只针对人类蛋白质组的 3%，但它们已经覆盖了人类生物学通路的 53%，是剖析人类生物学大部分内容的多功能工具包。现有药物靶向的途径可能富含未知但有效的药物靶点，可在未来的 "目标 2035 "工作中优先考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Chemical coverage of human biological pathways

Chemical probes and chemogenomic compounds are valuable tools to link gene to phenotype, explore human biology, and uncover novel targets for precision medicine. The mission of the Target 2035 initiative is to discover chemical tools for all human proteins by the year 2035. Here, we draw a landscape of the current chemical coverage of human biological pathways. Although available chemical tools target only 3% of the human proteome, they already cover 53% of human biological pathways and represent a versatile toolkit to dissect a vast portion of human biology. Pathways targeted by existing drugs may be enriched in unknown but valid drug targets and could be prioritized in future Target 2035 efforts.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.